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Invitrogen
SIRP beta/gamma Polyclonal Antibody
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产品信息
PA5-148568
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Mouse myeloma cell line NS0-derived recombinant human SIRP beta 1, Gly26-Ala369 (Arg53His and Ala363Pro)
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
SIRP beta and SIRP gamma are two members of the signal regulatory protein (SIRP) family. These proteins are transmembrane receptors that are expressed on the surface of various cells, including immune cells and neurons. The function of SIRP beta and SIRP gamma is to regulate cellular signaling pathways that are involved in immune responses, cell adhesion, and phagocytosis. Specifically, these proteins interact with the protein tyrosine phosphatase SHP-1, which is a negative regulator of immune cell activation. By binding to SHP-1, SIRP beta and SIRP gamma can inhibit immune cell activation and promote immune tolerance. In addition to their role in immune regulation, SIRP beta and SIRP gamma have also been implicated in neuronal signaling and synaptic plasticity. These proteins are thought to play a role in the formation and maintenance of synapses, as well as in the regulation of neuronal activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD172 antigen-like family member B; CD172b; CD172g; CD172g antigen; signal-regulatory protein beta 1; signal-regulatory protein beta 2; Signal-regulatory protein beta-1; Signal-regulatory protein beta-1 isoform 3; Signal-regulatory protein beta-2; Signal-regulatory protein gamma; SIRP beta 2; SIRP-b2; SIRP-beta-1; SIRP-beta-1 isoform 3; SIRP-beta-2; SIRP-gamma
基因别名: bA77C3.1; CD172b; CD172g; SIRP-B2; SIRP-BETA-1; SIRPB1; SIRPB2; SIRPG; SIRPgamma
UniProt ID: (Human) O00241, (Human) Q9P1W8
Entrez Gene ID: (Human) 10326, (Human) 55423
signal transduction
cell surface receptor signaling pathway
innate immune response
cell adhesion
cell-cell signaling
positive regulation of cell proliferation
negative regulation of cell proliferation
positive regulation of cell-cell adhesion
intracellular signal transduction
positive regulation of T cell activation
leukocyte migration
