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Invitrogen
SIRT2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-20487
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 19 amino acid peptide near the carboxy terminus of the human SIRT2.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
A suggested positive control is mouse brain tissue lysate.
PA5-20487 can be used with blocking peptide PEP-0607.
靶标信息
The SIRT2 protein (also known as Sirtuin for Silent Mating Type Information 2-Homolog) is a NAD-dependent deacytylase (NDAC) that has been shown to control gene silencing, cell cycle, and DNA damage repair. It is believed that SIRT2 may act as a tumor suppressor in human gliomas and may also serve as a novel molecular marker for these cells. SIRT2 has also been shown to act as a redox sensor to help regulate muscle gene expression in response to food intake and exercise. SIRT2 acts in the phosphorylation cascade involving mitosis where SIRT2 is phosphorylated in late G2 phase, during M phase, and into cytokinesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 5E5 antigen; mSIR2L2; NAD-dependent deacetylase sirtuin-2; NAD-dependent protein deacylase sirtuin-2; NAD-dependent protein defatty-acylase sirtuin-2; regulatory protein SIR2 homolog 2; silent information regulator 2; silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2; SIR2-h; SIR2-like protein 2; sir2-related protein type 2; sir2-related protein type 2; sirtuin type 2; NAD-dependent deacetylase sirtuin-2; silent information regulator 2; SIR2-like protein 2; regulatory protein SIR2; Sirt2; silent mating type information regulation 2; transcript variant 3; NAD-dependent deacetylase sirtuin-2; mSIR2L2; SIR2-like protein 2; NAD-dependent protein deacetylase sirtuin-2; sirtuin type 2; unnamed protein product; yeast silent information regulator 2 (Sir2p) homolog
基因别名: 5730427M03Rik; SIR2; SIR2L; SIR2L2
UniProt ID: (Human) Q8IXJ6, (Mouse) Q8VDQ8
Entrez Gene ID: (Human) 22933, (Mouse) 64383, (Rat) 361532
chromatin binding
NAD+ ADP-ribosyltransferase activity
histone deacetylase activity
protein binding
zinc ion binding
NAD-dependent histone deacetylase activity
protein deacetylase activity
NAD-dependent protein deacetylase activity
histone acetyltransferase binding
histone deacetylase binding
tubulin deacetylase activity
ubiquitin binding
NAD-dependent histone deacetylase activity (H4-K16 specific)
NAD binding
NAD+ binding
histone methacryllysine demethacrylase activity
histone benzoyllysine debenzoylase activity
DNA-binding transcription factor binding
NAD-dependent protein demyristoylase activity
NAD-dependent protein depalmitoylase activity
NAD-dependent protein lysine deacylase activity
protein ADP-ribosylase activity
negative regulation of transcription from RNA polymerase II promoter
chromatin silencing at rDNA
chromatin organization
protein deacetylation
ubiquitin-dependent protein catabolic process
fatty acid biosynthetic process
negative regulation of autophagy
negative regulation of peptidyl-threonine phosphorylation
lipid catabolic process
myelination in peripheral nervous system
regulation of myelination
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
cellular response to oxidative stress
peptidyl-lysine deacetylation
regulation of gene expression, epigenetic
negative regulation of protein catabolic process
regulation of apoptotic process
negative regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of DNA binding
post-translational protein modification
regulation of fat cell differentiation
negative regulation of fat cell differentiation
negative regulation of fatty acid biosynthetic process
positive regulation of fatty acid biosynthetic process
positive regulation of meiotic nuclear division
negative regulation of striated muscle tissue development
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of oligodendrocyte differentiation
regulation of cell cycle
positive regulation of cell division
positive regulation of attachment of spindle microtubules to kinetochore
cellular response to caloric restriction
negative regulation of oligodendrocyte progenitor proliferation
cellular response to hypoxia
cellular response to epinephrine stimulus
tubulin deacetylation
regulation of postsynaptic neurotransmitter receptor internalization
positive regulation of execution phase of apoptosis
positive regulation of oocyte maturation
negative regulation of NLRP3 inflammasome complex assembly
negative regulation of reactive oxygen species metabolic process
response to cocaine
regulation of cell differentiation
negative regulation of developmental process
chromatin remodeling
mitotic nuclear envelope reassembly
regulation of exit from mitosis
substantia nigra development
heterochromatin assembly
telomeric heterochromatin assembly
regulation of phosphorylation
regulation of lipid biosynthetic process
regulation of multicellular organismal process
response to redox state
negative regulation of satellite cell differentiation
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