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Invitrogen
SIRT4 Polyclonal Antibody
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产品信息
PA5-83095
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
规格
10 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: VLQERFQVLN PTWSAEAHGL APDGDVFLSE EQVRSFQVPT CVQCGGHLKP DVVFFGDTVN PDKVDFVHKR VKEADSLLVV GS
Highest antigen sequence indentity to the following orthologs: Rat - 85%, Mouse - 88%.
靶标信息
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MGC130046; MGC130047; MGC57437; NAD-dependent ADP-ribosyltransferase sirtuin-4; NAD-dependent protein biotinylase sirtuin-4; NAD-dependent protein deacetylase sirtuin-4; NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Regulatory protein SIR2 homolog 4; sir2-like 4; SIR2-like protein 4; sirtuin type 4; yeast silent information regulator 2 (Sir2p) homolog; similar to prokaryotic sirtuins
基因别名: SIR2L4; SIRT4
UniProt ID: (Human) Q9Y6E7
Entrez Gene ID: (Human) 23409
NAD+ ADP-ribosyltransferase activity
histone deacetylase activity
protein binding
zinc ion binding
transferase activity
transferase activity, transferring acyl groups other than amino-acyl groups
transferase activity, transferring glycosyl groups
nucleotidyltransferase activity
NAD-dependent protein deacetylase activity
metal ion binding
NAD binding
lipoamidase activity
NAD+ binding
NAD-dependent protein lipoamidase activity
NAD-dependent protein biotinidase activity
NAD+-protein-cysteine ADP-ribosyltransferase activity
protein ADP-ribosylase activity
regulation of glutamine family amino acid metabolic process
glutamine metabolic process
cellular response to DNA damage stimulus
mitochondrion organization
negative regulation of cardiac muscle cell apoptotic process
peptidyl-lysine deacetylation
negative regulation of fatty acid oxidation
negative regulation of insulin secretion
positive regulation of lipid biosynthetic process
cellular response to hypoxia
tricarboxylic acid metabolic process
negative regulation of pyruvate decarboxylation to acetyl-CoA
negative regulation of protein processing involved in protein targeting to mitochondrion
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