Invitrogen

SIRT4 Polyclonal Antibody

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说明书
实验方案
问题与答案
技术支持
SIRT4 Polyclonal Antibody

产品信息

PA5-96727

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫组化（石蜡） (IHC (P))

1:50-1:200
-

酶联免疫吸附实验 (ELISA)

1 µg/mL
-

亲和纯化 (AP)

-
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产品规格

种属反应

Human, Mouse, Rat

已发表种属

C. elegans

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 29-313 of human SIRT4 (NP_0363721)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

6.79 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.05% ProClin 300

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2808529

产品详细信息

Positive Samples: Mouse liver, Mouse heart, Rat lung; Cellular Location: Mitochondrion matrix

Immunogen sequence: IGLFVPASPP LDPEKVKELQ RFITLSKRLL VMTGAGISTE SGIPDYRSEK VGLYARTDRR PIQHGDFVRS APIRQRYWAR NFVGWPQFSS HQPNPAHWAL STWEKLGKLY WLVTQNVDAL HTKAGSRRLT ELHGCMDRVL CLDCGEQTPR GVLQERFQVL NPTWSAEAHG LAPDGDVFLS EEQVRSFQVP TCVQCGGHLK PDVVFFGDTV NPDKVDFVHK RVKEADSLLV VGSSLQVYSG YRFILTAWEK KLPIAILNIG PTRSDDLACL KLNSRCGELL PLIDP

靶标信息

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: MGC130046; MGC130047; MGC57437; NAD-dependent ADP-ribosyltransferase sirtuin-4; NAD-dependent protein biotinylase sirtuin-4; NAD-dependent protein deacetylase sirtuin-4; NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Regulatory protein SIR2 homolog 4; sir2-like 4; SIR2-like protein 4; SIRT4; sirtuin type 4

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基因别名: 4930596O17Rik; SIR2L4; SIRT4

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UniProt ID: (Human) Q9Y6E7, (Mouse) Q8R216

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Entrez Gene ID: (Human) 23409, (Mouse) 75387, (Rat) 304539

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功能
NAD+ ADP-ribosyltransferase activity protein binding zinc ion binding NAD-dependent protein deacetylase activity biotinidase activity lipoamidase activity NAD+ binding imidazoleglycerol-phosphate synthase activity histone deacetylase activity protein-N-terminal asparagine amidohydrolase activity UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity transferase activity hydrolase activity NAD(P)-cysteine ADP-ribosyltransferase activity NAD(P)-asparagine ADP-ribosyltransferase activity NAD(P)-serine ADP-ribosyltransferase activity iprodione amidohydrolase activity (3,5-dichlorophenylurea)acetate amidohydrolase activity 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity didemethylisoproturon amidohydrolase activity N-isopropylacetanilide amidohydrolase activity N-cyclohexylformamide amidohydrolase activity isonicotinic acid hydrazide hydrolase activity cis-aconitamide amidase activity gamma-N-formylaminovinylacetate hydrolase activity N2-acetyl-L-lysine deacetylase activity O-succinylbenzoate synthase activity indoleacetamide hydrolase activity 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity N-acetylcitrulline deacetylase activity purine deoxyribosyltransferase activity metal ion binding N-acetylgalactosamine-6-phosphate deacetylase activity diacetylchitobiose deacetylase activity chitooligosaccharide deacetylase activity molecular_function
参与通路
protein ADP-ribosylation glutamine metabolic process cellular response to DNA damage stimulus negative regulation of cardiac muscle cell apoptotic process peptidyl-lysine deacetylation negative regulation of fatty acid oxidation negative regulation of insulin secretion positive regulation of lipid biosynthetic process tricarboxylic acid metabolic process negative regulation of protein processing involved in protein targeting to mitochondrion regulation of glutamine family amino acid metabolic process chromatin silencing cellular response to hypoxia regulation of pyruvate dehydrogenase activity
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