Invitrogen

SLC11A2 Polyclonal Antibody

查看其他11个SLC11A2抗体

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说明书
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问题与答案
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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
SLC11A2 Polyclonal Antibody

产品信息

PA5-87729

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:2,000
-

免疫组化（石蜡） (IHC (P))

1:50-1:200
-

酶联免疫吸附实验 (ELISA)

1 µg/mL
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein (or fragment)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.41 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.09% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2804372

产品详细信息

Immunogen sequence: MVLGPEQKMS DDSVSGDHGE SASLGNINPA YSNPSLSQSP GDSEEYFATY FNEKISIPEE EYS

Positive Samples: U-87MG, LO2, SW620, NCI-H460, Mouse kidney, Mouse spleen, Mouse testis, Rat kidney, Rat testis; Cellular Location: Cell membrane, Early endosome, Endosome membrane, Mitochondrion outer membrane, Multi-pass membrane protein

靶标信息

This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Dct-1; Divalent cation transporter 1; Divalent metal transporter 1; DMT-1; microcytic anemia, viable anaemia; Natural resistance-associated macrophage protein 2; NRAMP 2; solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2; Solute carrier family 11 member 2; Solute carrier family 11 member 2 (natural resistance-associated macrophage protein 2)

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基因别名: AHMIO1; DCT1; DMT1; mk; NRAMP2; OK/SW-cl.20; SLC11A2; van

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UniProt ID: (Human) P49281, (Mouse) P49282, (Rat) O54902

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Entrez Gene ID: (Human) 4891, (Mouse) 18174, (Rat) 25715

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功能
copper ion transmembrane transporter activity iron ion transmembrane transporter activity manganese ion transmembrane transporter activity protein binding hydrogen ion transmembrane transporter activity cadmium ion transmembrane transporter activity cobalt ion transmembrane transporter activity ferrous iron transmembrane transporter activity lead ion transmembrane transporter activity solute:proton symporter activity ferrous iron uptake transmembrane transporter activity transferrin transmembrane transporter activity cadmium ion binding transition metal ion transmembrane transporter activity transporter activity iron ion binding copper ion binding zinc ion binding nickel cation transmembrane transporter activity vanadium ion transmembrane transporter activity nickel cation binding inorganic cation transmembrane transporter activity manganese ion binding cobalt ion binding zinc ion transmembrane transporter activity calcium ion transmembrane transporter activity chromium ion transmembrane transporter activity secondary carrier transporter
参与通路
heme biosynthetic process cobalt ion transport copper ion transport manganese ion transport cellular iron ion homeostasis learning or memory response to iron ion ferrous iron transport lead ion transport transferrin transport copper ion transmembrane transport dendrite morphogenesis erythrocyte development multicellular organismal iron ion homeostasis cadmium ion transmembrane transport ferrous iron import manganese ion transmembrane transport hydrogen ion transmembrane transport ferrous iron transmembrane transport transition metal ion transport porphyrin-containing compound metabolic process porphyrin-containing compound biosynthetic process transport ion transport iron ion transport cellular copper ion homeostasis activation of cysteine-type endopeptidase activity involved in apoptotic process response to manganese ion nickel cation transport vanadium ion transport proton transport cellular response to oxidative stress iron ion transmembrane transport nickel cation transmembrane transport iron ion homeostasis zinc II ion transmembrane transport cation transmembrane transport copper ion import into cell response to hypoxia detection of oxygen response to lead ion response to cadmium ion cellular response to iron ion cellular response to tumor necrosis factor cellular response to hypoxia
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