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Invitrogen
SLC24A2 Polyclonal Antibody
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SLC24A2 Antibody (PA5-104164) in IHC (P)
Immunohistochemistry analysis of SLC24A2 in human gastric cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with SLC24A2 polyclonal antibody (Product # PA5-104164) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-104164
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human SLC24A2(Accession Q9UI40), corresponding to amino acid residues P311-L361.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total SLC24A2.
靶标信息
NCKX2, also designated solute carrier family 24, member 2 (SLC24A2), belongs to a family of potassium-dependent sodium/calcium exchangers, all of which contain two large hydrophilic loops and two sets of multiple transmembrane-spanning segments. NCKX2 is expressed in neurons throughout the brain, with high expression found in cone photoreceptors in the retina as well as hippocampal pyramidal cells and the deep nuclei of the cerebellum. A critical component in the process of light adaptation, NCKX2 transports one calcium ion and one potassium ion in exchange for four sodium ions, thereby contolling calcium concentration in the eye during light and darkness. Additionally, NCKX2 regulates calcium levels in other cellular locations that experience rapid calcium fluxes, such as neuronal synapses. Inactivation of NCKX2 is believed to be an important regulatory mechanism in the control of sodium and calcium levels under different physiological conditions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Na(+)/K(+)/Ca(2+)-exchange protein 2; potassium-dependent sodium-calcium exchanger; Retinal cone Na-Ca+K exchanger; Sodium/potassium/calcium exchanger 2; solute carrier family 24 (sodium/potassium/calcium exchanger), member 2; Solute carrier family 24 member 2; solute carrier family 24, member 2
基因别名: 2810021B17Rik; 6330417K15Rik; AI847460; NCKX2; SLC24A2
UniProt ID: (Human) Q9UI40, (Mouse) Q8BUN9, (Rat) O54701
Entrez Gene ID: (Human) 25769, (Mouse) 76376, (Rat) 84550
ion transport
potassium ion transport
cellular calcium ion homeostasis
visual perception
learning
memory
ion transmembrane transport
sodium ion transmembrane transport
response to stimulus
long-term synaptic potentiation
long term synaptic depression
calcium ion transmembrane transport
calcium ion transport
potassium ion transmembrane transport
