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Invitrogen
SLC24A2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-145209
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 374-470.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.2 mg/mL
规格
20 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: TEEGRFREKA SILHKIAKKK CHVDENERQN GAANHVEKIE LPNSTSTDVE MTPSSDASEP VQNGNLSHNI EGAEAQTADE EEDQPLSLAW PSETRKQ
Antigen sequence identity: Mouse 89%; Rat 81%
靶标信息
NCKX2, also designated solute carrier family 24, member 2 (SLC24A2), belongs to a family of potassium-dependent sodium/calcium exchangers, all of which contain two large hydrophilic loops and two sets of multiple transmembrane-spanning segments. NCKX2 is expressed in neurons throughout the brain, with high expression found in cone photoreceptors in the retina as well as hippocampal pyramidal cells and the deep nuclei of the cerebellum. A critical component in the process of light adaptation, NCKX2 transports one calcium ion and one potassium ion in exchange for four sodium ions, thereby contolling calcium concentration in the eye during light and darkness. Additionally, NCKX2 regulates calcium levels in other cellular locations that experience rapid calcium fluxes, such as neuronal synapses. Inactivation of NCKX2 is believed to be an important regulatory mechanism in the control of sodium and calcium levels under different physiological conditions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Na(+)/K(+)/Ca(2+)-exchange protein 2; Na/Ca-K exchanger 2; NCKX family member; retinal cone Na-Ca+K exchanger; solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
基因别名: NCKX2
UniProt ID: (Human) Q9UI40
Entrez Gene ID: (Human) 25769
cellular calcium ion homeostasis
phototransduction
ion transmembrane transport
sodium ion transmembrane transport
cone photoresponse recovery
transmembrane transport
long-term synaptic potentiation
long term synaptic depression
calcium ion import
calcium ion transmembrane transport
cellular response to high light intensity
potassium ion transmembrane transport
calcium ion import across plasma membrane
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
