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Invitrogen
SLC4A8 Polyclonal Antibody
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SLC4A8 Antibody (PA5-101904) in ICC/IF
Immunocytochemistry analysis of SLC4A8/SLC4A10 in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with SLC4A8/SLC4A10 polyclonal antibody (Product # PA5-101904) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
产品信息
PA5-101904
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human SLC4A8(Accession Q2Y0W8), corresponding to amino acid residues F1040-S1090.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total SLC4A8/10.
靶标信息
Mediates electroneutral sodium- and carbonate-dependent choride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Electroneutral Na(+)-driven Cl-HCO3 exchanger; Electroneutral Na+-driven Cl-HCO3 exchanger; Electroneutral sodium bicarbonate exchanger 1; k-NBC3; Na-driven Cl-HCO3 exchanger NDCBE1-A; Na-driven Cl-HCO3 exchanger NDCBE1-B; Na-driven Cl-HCO3 exchanger NDCBE1-C; slc4a8; slc4a8 {ECO:0000312|RGD:735164}; sodium bicarbonate cotransporter isoform 3 kNBC-3; solute carrier family 4 (anion exchanger), member 8; Solute carrier family 4 member 8; solute carrier family 4, sodium bicarbonate cotransporter, member 8
基因别名: AW493845; C230026C11; KIAA0739; kNBC-3; NBC; NBC3; NDCBE; NDCBE1; SLC4A8
UniProt ID: (Human) Q2Y0W8, (Mouse) Q8JZR6, (Rat) Q6RVG2
Entrez Gene ID: (Human) 9498, (Mouse) 59033, (Rat) 315311
