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Invitrogen
SLC6A4 Polyclonal Antibody
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SLC6A4 Antibody (PA5-87190) in IHC (P)
Immunohistochemistry analysis of SLC6A4 in paraffin-embedded human colon. Samples were incubated with SLC6A4 polyclonal antibody (Product # PA5-87190) using a dilution of 1:100. Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-87190
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide of human SLC6A4
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Purity is > 95% by SDS-PAGE.
靶标信息
SERT is an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 5 OCD1; 5-hydroxytryptamine (serotonin) transporter; 5HT transporter; 5HTT; HGNC:11050; hSERT; Na+/Cl- dependent serotonin transporter; OTTHUMP00000163633; serotonin transporter; serotonin transporter 1; Sodium-dependent serotonin transporter (5HT transporter) (5HTT); Solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter); solute carrier family 6 (neurotransmitter transporter), member 4; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; solute carrier family 6 member 4; unnamed protein product
基因别名: 5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1; SERT; SERT1
UniProt ID: (Human) P31645, (Mouse) Q60857, (Rat) P31652
Entrez Gene ID: (Human) 6532, (Mouse) 15567, (Rat) 25553
integrin binding
cation channel activity
neurotransmitter transporter activity
serotonin:sodium symporter activity
protein binding
monoamine transmembrane transporter activity
antiporter activity
cocaine binding
sodium ion binding
identical protein binding
nitric-oxide synthase binding
actin filament binding
serotonin binding
syntaxin-1 binding
response to hypoxia
neurotransmitter transport
amino acid transport
serotonin receptor signaling pathway
response to nutrient
memory
circadian rhythm
locomotory behavior
response to xenobiotic stimulus
response to toxic substance
positive regulation of gene expression
positive regulation of serotonin secretion
negative regulation of cerebellar granule cell precursor proliferation
regulation of transmembrane transporter activity
negative regulation of synaptic transmission, dopaminergic
response to estradiol
sodium ion transmembrane transport
vasoconstriction
negative regulation of neuron differentiation
positive regulation of cell cycle
negative regulation of organ growth
behavioral response to cocaine
enteric nervous system development
brain morphogenesis
serotonin uptake
membrane depolarization
male mating behavior
platelet aggregation
cellular response to retinoic acid
cellular response to cGMP
regulation of thalamus size
neurotransmitter reuptake
response to oxidopamine
conditioned place preference
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