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Invitrogen
SLC6A4 Monoclonal Antibody (632705)
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产品信息
MA5-61034
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
632705
抗原
Human SLC6A4/5-HTTLPR synthetic peptide
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
SERT is an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 5 OCD1; 5-hydroxytryptamine (serotonin) transporter; 5HT transporter; 5HTT; HGNC:11050; Na+/Cl- dependent serotonin transporter; OTTHUMP00000163633; serotonin transporter 1; SERT; Sodium-dependent serotonin transporter; solute carrier family 6 (neurotransmitter transporter), member 4; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; Solute carrier family 6 member 4
基因别名: 5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1; SERT; SERT1; SLC6A4
UniProt ID: (Human) P31645
Entrez Gene ID: (Human) 6532
serotonin:sodium symporter activity
protein binding
monoamine transmembrane transporter activity
serotonin transmembrane transporter activity
myosin binding
syntaxin-1 binding
Rab GTPase binding
cocaine binding
protein homodimerization activity
metal ion binding
nitric-oxide synthase binding
actin filament binding
primary active transporter
response to hypoxia
serotonin transport
chemical synaptic transmission
response to nutrient
memory
circadian rhythm
response to toxic substance
positive regulation of gene expression
monoamine transport
thalamus development
negative regulation of cerebellar granule cell precursor proliferation
negative regulation of synaptic transmission, dopaminergic
response to estradiol
social behavior
vasoconstriction
response to drug
sperm ejaculation
negative regulation of neuron differentiation
positive regulation of cell cycle
negative regulation of organ growth
brain morphogenesis
protein oligomerization
protein homooligomerization
serotonin uptake
transmembrane transport
cellular response to retinoic acid
cellular response to cGMP
