Invitrogen

SLIT2 Polyclonal Antibody

2个已发表图片
4 篇参考文献
查看其他11个SLIT2抗体

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说明书
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问题与答案
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说明书
实验方案
问题与答案
技术支持

产品信息

PA5-31133

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:10,000
查看1篇已发表文章 1篇已发表文章

免疫组化 (IHC)

-
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免疫组化（石蜡） (IHC (P))

1:100-1:1,000
-

染色质免疫沉淀 实验 (ChIP)

-
查看1篇已发表文章 1篇已发表文章
产品规格

种属反应

Human, Mouse, Rat

已发表种属

C. elegans, Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein encompassing a sequence within the center region of human SLIT2. The exact sequence is proprietary.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.41 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 1% BSA, 20% glycerol

内含物

0.025% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2548607

产品详细信息

Recommended positive controls: IMR32, SK-N-AS, mouse brain, rat brain, SLIT2-transfected 293T.

Predicted reactivity: Mouse (98%), Rat (95%), Zebrafish (88%), Xenopus laevis (93%), Chicken (97%), Bovine (99%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

SLIT2 are ligands for Robo receptors and play a vital role for axonal migration/navigation during neural development. A number of cleavage products through alternate splicing are reported in the literature for SLIT2 proteins. The C-terminal cleavage proteins are more diffusible than the larger N-terminal protein that is more tightly cell associated. SLIT2 protein is expressed in tissues such as fetal lung, kidney, and adult spinal cord.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: downregulated during adipocyte differentiation-1; neurogenic extracellular slit protein; Slit homolog 2 protein; Slit-2

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基因别名: Drad-1; E030015M03Rik; E130320P19Rik; mKIAA4141; SLIL3; Slit-2; SLIT2

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UniProt ID: (Human) O94813, (Mouse) Q9R1B9

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Entrez Gene ID: (Human) 9353, (Rat) 360272, (Mouse) 20563

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功能
GTPase inhibitor activity calcium ion binding protein binding heparin binding identical protein binding protein homodimerization activity laminin-1 binding proteoglycan binding heparan sulfate proteoglycan binding Roundabout binding follicle-stimulating hormone receptor activity chemorepellent activity receptor binding immunoglobulin superfamily cell adhesion molecule
参与通路
ureteric bud development negative regulation of protein phosphorylation cell migration involved in sprouting angiogenesis negative regulation of leukocyte chemotaxis axon guidance motor neuron axon guidance negative regulation of lamellipodium assembly negative regulation of endothelial cell migration negative regulation of smooth muscle cell migration spinal cord development chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration chemorepulsion involved in postnatal olfactory bulb interneuron migration corticospinal neuron axon guidance through spinal cord negative regulation of cell growth negative regulation of cell migration negative regulation of actin filament polymerization retinal ganglion cell axon guidance response to nutrient levels cellular response to hormone stimulus negative regulation of GTPase activity Roundabout signaling pathway positive regulation of apoptotic process negative regulation of vascular permeability branching morphogenesis of an epithelial tube axon extension involved in axon guidance negative regulation of inflammatory response positive regulation of axonogenesis negative chemotaxis induction of negative chemotaxis negative regulation of small GTPase mediated signal transduction response to cortisol apoptotic process involved in luteolysis negative regulation of chemokine-mediated signaling pathway cellular response to heparin negative regulation of smooth muscle cell chemotaxis negative regulation of mononuclear cell migration negative regulation of neutrophil chemotaxis negative regulation of monocyte chemotaxis negative regulation of retinal ganglion cell axon guidance negative regulation of cellular response to growth factor stimulus metanephros development in utero embryonic development chemotaxis axonogenesis brain development negative regulation of cell proliferation negative regulation of gene expression single organismal cell-cell adhesion olfactory bulb development telencephalon cell migration cell differentiation negative regulation of axon extension dorsal/ventral axon guidance follicle-stimulating hormone signaling pathway negative regulation of catalytic activity neuron projection morphogenesis mammary gland duct morphogenesis mammary duct terminal end bud growth multicellular organism development nervous system development
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