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Invitrogen
SMAD1/SMAD5/SMAD9 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA1-41079
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Two synthetic peptides corresponding to amino acids 19-33 and amino acids 315-329 of human SMAD1.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein G
保存液
PBS
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is predicted to react with chicken, chimpanzee, invertebrates, mammals, porcine, xenopus and zebrafish based on sequence homology.
Immunogen sequence: GWKQGDEEEK WAEKA & SNVNRNSTIE NTRRH
靶标信息
The protein encoded by SMAD1/SMAD5/SMAD8/SMAD9 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BSP-1; Dwarfin-A; Dwarfin-C; Dwf-A; Dwf-C; JV4-1; JV5-1; MAD homolog 1; MAD homolog 5; MAD homolog 9; Mad-related protein 1; Madh6; mMad1; Mothers against decapentaplegic homolog 1; Mothers against decapentaplegic homolog 5; Mothers against decapentaplegic homolog 9; mothers against DPP homolog 1; mothers against DPP homolog 5; mothers against DPP homolog 9; Mothers-against-DPP-related 1; mSmad5; SMAD; SMAD 1; SMAD 5; SMAD 9; SMAD family member 1; SMAD family member 5; SMAD family member 9; Transforming growth factor-beta-signaling protein 1
基因别名: 1110051M15Rik; AI451355; AI528653; BSP1; Dwf-C; MADH1; MADH5; MADH6; Madh8; MADH9; MADR1; Mlp1; Msmad5; MusMLP; SMAD1; SMAD5; SMAD8; SMAD9
UniProt ID: (Mouse) P70340, (Mouse) P97454, (Mouse) Q9JIW5
Entrez Gene ID: (Mouse) 17125, (Mouse) 17129, (Mouse) 55994
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein kinase binding
identical protein binding
protein homodimerization activity
metal ion binding
protein heterodimerization activity
co-SMAD binding
I-SMAD binding
ubiquitin protein ligase binding
DNA-binding transcription factor
gene-specific transcriptional regulator
MAPK cascade
mesodermal cell fate commitment
osteoblast fate commitment
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
protein phosphorylation
transforming growth factor beta receptor signaling pathway
SMAD protein complex assembly
gamete generation
negative regulation of cell proliferation
positive regulation of gene expression
BMP signaling pathway
midbrain development
hindbrain development
response to drug
homeostatic process
positive regulation of cell differentiation
positive regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
cartilage development
cardiac muscle cell proliferation
bone development
positive regulation of cartilage development
cellular response to organic cyclic compound
cellular response to BMP stimulus
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
angiogenesis
Mullerian duct regression
multicellular organism development
germ cell development
cell differentiation
erythrocyte differentiation
cardiac muscle contraction
positive regulation of transcription, DNA-templated
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