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Immunogen sequence: MAEGLERVRI SASELRGILA TLAPQAGSRE NMKELKEARP RKDNRRPDLE IYKPGLSRLR NKPKIKEPPG SEEFKDEIVN DRDCSAVENG TQPVKDVCKE LNNQEQNGPI DP
Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 85%.
This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: EST1 telomerase component homolog A; Ever shorter telomeres 1A; hEST1A; hSmg5/7a; Nonsense mediated mRNA decay factor SMG6; Smg-6 homolog; smg-6 homolog, nonsense mediated mRNA decay factor; SMG6 nonsense mediated mRNA decay factor; telomerase subunit EST1A; Telomerase-binding protein EST1A
基因别名: C17orf31; EST1A; hSMG5/7a; KIAA0732; SMG-6; SMG6
UniProt ID: (Human) Q86US8
Entrez Gene ID: (Human) 23293
分子生物学功能: RNA metabolism protein