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Invitrogen
SMN1/SMN2 Monoclonal Antibody (2B1)
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SMN1/SMN2 Antibody (MA1-5878) in ICC/IF
Immunocytochemistry analysis of SMN1/SMN2 on paraformaldehyde fixed HeLa cells, permeabilized with 0.15% Triton. Samples were incubated with SMN1/SNM2 monoclonal antibody (Product # MA1-5878) using a dilution of 1:100 for 1hr. Followed by Alexa Fluor® 488 secondary antibody at a 1:1,000 dilution, showing cytoplasmic and nuclear bodies staining. The nuclear stain is DAPI (blue). Negative control: Mouse IgG1 ... View More
产品信息
MA1-5878
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Xenopus
已发表种属
Rabbit
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
2B1
抗原
Purified recombinant His 6 tagged-SMN protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA1-5878 detects SMN in human, mouse and xenopus samples.
MA1-5878 has been successfully used in Western blot, immunoprecipitation, immunofluorescence, immunohistochemistry (paraffin), flow cytometry, and ELISA procedures. MA1-5878 detects a band of approximately 42kDa.
The MA1-5878 immunogen is purified recombinant His 6 tagged-SMN protein (human).
靶标信息
The SMN1 gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein - survival motor neuron protein. The SMN complex plays a catalyst role in the assemble of small nuclear ribonucleoproteins, the building blocks of the spliceosome. Mutations in the SMN1 gene are known to cause spinal muscular atrophy 1/2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Component of gems 1; Gemin-1; survival motor neuron 1 protein; Survival motor neuron protein; survival of motor neuron protein; tudor domain containing 16A
基因别名: AI849087; BCD541; GEMIN1; SMA; SMA1; SMA2; SMA3; SMA4; SMA@; SMN; SMN1; SMN2; SMNC; SMNT; T-BCD541; TDRD16A
UniProt ID: (Human) Q16637, (Mouse) P97801
Entrez Gene ID: (Human) 6606, (Mouse) 20595
