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产品信息
PA5-31392
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
C. elegans,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human SMOC1. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
0.05 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol, 1% BSA
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: U87-MG.
Predicted reactivity: Mouse (96%), Rat (95%), Xenopus laevis (84%), Bovine (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Secreted modular calcium-binding protein 1 (SMOC1) is a gene located on chromosome 14q24.2, encoding a member of the SPARC (Secreted Protein, Acidic, and Rich in Cysteine) family of matricellular proteins. SMOC1 is characterized by its multiple domains that facilitate calcium binding and interaction with various components of the extracellular matrix. This protein plays a crucial role in modulating cell-matrix interactions and signaling pathways involved in cellular adhesion, migration, and differentiation. SMOC1 is expressed in multiple tissues, including the eyes, limbs, and the central nervous system, and is essential for developmental processes such as angiogenesis and tissue formation. Mutations in SMOC1 have been linked to ocular conditions like anterior segment dysgenesis and microphthalmia, reflecting its significance in eye development. Current studies focus on the protein's broader implications in developmental disorders and its potential as a therapeutic target in diseases associated with extracellular matrix dysregulation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Secreted modular calcium-binding protein 1; SMOC-1; SPARC-related modular calcium-binding protein 1
基因别名: OAS; SMOC1
UniProt ID: (Human) Q9H4F8
Entrez Gene ID: (Human) 64093
