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Invitrogen
SMUG1 Polyclonal Antibody
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SMUG1 Antibody (PA5-120070) in WB
Western blot analysis of SMUG1 in extracts of various cell lines. Samples were incubated with SMUG1 Polyclonal antibody (Product # PA5-120070) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 30s.
产品信息
PA5-120070
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human SMUG1 (NP_055126.1).
偶联物
形式
Liquid
浓度
0.4 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive test controls include: LO2, Mouse kidney, Mouse liver, Mouse lung. The target is usually found in the following locations: Nucleus.
Immunogen sequence: MPQAFLLGSI HEPAGALMEP QPCPGSLAES FLEEELRLNA ELSQLQFSEP VGIIYNPVEY AWEPHRNYVT RYCQGPKEVL FLGMNPGPFG MAQTGVPFGE VSMVRDWLGI VGPVLTPPQE HPKRPVLGLE CPQSEVSGAR FWGFFRNLCG QPEVFFHHCF VHNLCPLLFL APSGRNLTPA ELPAKQREQL LGICDAALCR QVQLLGVRLV VGVGRLAEQR ARRALAGLMP EVQVEGLLHP SPRNPQANKG WEAVAKERLN ELGLLPLLLK
靶标信息
SMUG1 is a glycosylase that removes uracil from single- and double-stranded DNA in nuclear chromatin, thus contributing to base excision repair.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MGC104370; Single-strand selective monofunctional uracil DNA glycosylase
基因别名: 1200013B09Rik; A930006H09Rik; C85220; FDG; HMUDG; SMUG1; UNG3
UniProt ID: (Human) Q53HV7, (Mouse) Q6P5C5
Entrez Gene ID: (Human) 23583, (Mouse) 71726
oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
DNA binding
uracil DNA N-glycosylase activity
protein binding
single-strand selective uracil DNA N-glycosylase activity
DNA N-glycosylase activity
purine-specific mismatch base pair DNA N-glycosylase activity
oxidized base lesion DNA N-glycosylase activity
single-stranded DNA binding
hydrolase activity
hydrolase activity, acting on glycosyl bonds
DNA-3-methylbase glycosylase activity
nicotinamide riboside hydrolase activity
nicotinic acid riboside hydrolase activity
deoxyribonucleoside 5'-monophosphate N-glycosidase activity
DNA metabolism protein
DNA glycosylase
nucleic acid metabolism protein
