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Abnova
SNCAIP Polyclonal Antibody, MaxPab™
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产品信息
H00009627-B01P
产品规格
种属反应
Human,
Rat
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
SNCAIP (AAH94759.1, 1 a.a. approximately 603 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MTYLIQSHHS RRSQNCAEDV IRKTKTDQNG QLECVRWMVS ETEAIAELSC SKDFPSLIHY AGCYGQEKIL LWLLQFMQEQ GISLDEVDQD GNSAVHVASQ HGYLGCIQTL VEYGANVTMQ NHAGEKPSQS AERQGHTLCS RYLVVVETCM SLASQVVKLT KQLKEQTVER VTLQNQLQQF LEAQKSEGKS LPSSPSSPSS PASRKSQWKS PDADDDSVAK SKPGVQEGIQ VLGSLSASSR ARPKAKDEDS DKILRQLLGK EISENVCTQE KLSLEFQDAQ ASSRNSKKIP LEKRELKLAR LRQLMQRSLS ESDTDSNNSE DPKTTPVRKA DRPRPQPIVE SVESMGSAES LHLMIKKHTL ASGGRRFPFS IKASKSLDGH SPSPTSESSE PDLESQYPGS GSIPPNQPSG DPQQPSPDST AAQKVATSPK SALKSPSSKR RTSQNLKLRV TFEEPVVQME QPSLELNGEK DKDKGRTLQR TSTSNESGDQ LKRPFGAFRS IMETLSGNQN NNNNYQAANQ LKTSTLPLTS LGRKTDAKGN PASSASKGKN KAEMYSSCIN LSSNMLIEEH LCNDTRHNDI NRKMKKSYSI KHIAEPESKE LFL
靶标信息
Parkinson is the second most common neurodegenerative disease after Alzheimer's. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. Synuclein alpha interacting protein (Synphilin-1) contains several protein-protein interaction domains and interacts with alpha synuclein in neurons. Mutations of SNCAIP have been linked to Parkinson disease. The amino acid sequence of synphilin-1 shows extensive homology with its human counterpart, especially in regions containing ankyrin-like motifs and the coiled-coil domain. Expression of mouse synphilin-1 in tissues is similar to its human counterpart. Synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1. Role of synphilin-1 in synaptic function and protein degradation and in the molecular mechanisms leading to neurodegeneration in Parkinson disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alpha-synuclein-interacting protein; MGC39814; Sph1; Synphilin 1; Synphilin-1; synuclein, alpha interacting protein; synuclein, alpha interacting protein (synphilin)
基因别名: SNCAIP; Sph1; SYPH1
UniProt ID: (Human) Q49AC6
Entrez Gene ID: (Human) 9627, (Rat) 307309
