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Invitrogen
SNX2 Polyclonal Antibody
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产品信息
PA5-23281
产品规格
种属反应
Bovine,
Dog,
Horse,
Human,
Marsupial,
Mouse,
Non-human primate,
Rhesus monkey
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A portion of amino acids 350-400 of human Snx2.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Sequence homology: Platypus/chimpanzee (100%).
靶标信息
Sorting nexin 2 (SNX2) is a gene located on human chromosome 5q23.3 that encodes a protein involved in various cellular processes, primarily associated with endosomal sorting and intracellular trafficking. SNX2, along with SNX1, forms part of the sorting nexin family characterized by the presence of a Phox (PX) domain, which binds phosphoinositides and facilitates the interaction with membrane compartments such as endosomes. Functionally, SNX2 plays roles in the retrograde transport of Shiga toxin from endosomes to the Golgi apparatus, as well as regulation of endosome-endoplasmic reticulum contact sites through interaction with VAP proteins at the ER membrane. Additionally, SNX2 is implicated in autophagy initiation during nutrient starvation by facilitating the tubulation of early endosomes toward ER sites. As a membrane-associated protein, SNX2 is essential for protein trafficking and retrieval of transmembrane proteins, thus contributing to cellular homeostasis and the dynamic remodeling of endosomal zones.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CTB-36H16.2; MGC5204; Sorting nexin-2; Transformation-related gene 9 protein; TRG-9
基因别名: 0610030A03Rik; SNX2; TRG-9; TRG9
UniProt ID: (Human) O60749, (Bovine) Q2TBW7, (Mouse) Q9CWK8
Entrez Gene ID: (Human) 6643, (Rhesus monkey) 700507, (Horse) 100073099, (Bovine) 509769, (Dog) 474657, (Mouse) 67804
epidermal growth factor receptor binding
insulin receptor binding
protein binding
phosphatidylinositol binding
protein homodimerization activity
protein heterodimerization activity
cadherin binding involved in cell-cell adhesion
transferrin receptor binding
leptin receptor binding
lipid binding
scaffold/adaptor protein
