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Invitrogen
SOCS7 Recombinant Rabbit Monoclonal Antibody (24GB1820)
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SOCS7 Antibody (MA5-57271) in WB
Western blot analysis of SOCS7. Total cell lysates (30 μg) from C2C12, H9c2, HAP-1, HeLa, HepG2, and HT-1080 cell lines were loaded and separated by SDS-PAGE. The blot was incubated with SOCS7 Recombinant Monoclonal Antibody (Product # MA5-57271) at a 1:5,000 dilution and HRP-conjugated goat anti-rabbit secondary antibody at a 1:20,000 dilution respectively.
产品信息
MA5-57271
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
24GB1820
抗原
A synthesized peptide derived from human SOCS7 (aa 1-50)
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Dry ice (international)
RRID
靶标信息
SOCS7 regulates signaling cascades probably through protein ubiquitination and/or sequestration. SOCS7 functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. SOCS7 inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. SOCS7 may be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: NAP-4; Nck, Ash and phospholipase C binding protein; Nck, Ash and phospholipase C gamma-binding protein; NCK-associated protein 4; SH2 domain containing SOCS box protein SOCS7; SOCS-7; Suppressor of cytokine signaling 7
基因别名: 2310063P06Rik; C85125; Cish7; NAP4; NCKAP4; SOCS6; SOCS7
UniProt ID: (Human) O14512, (Mouse) Q8VHQ2
Entrez Gene ID: (Human) 30837, (Rat) 287659, (Mouse) 192157
negative regulation of protein kinase activity
biological_process
insulin receptor signaling pathway
protein ubiquitination
cytokine-mediated signaling pathway
layer formation in cerebral cortex
radial glia guided migration of Purkinje cell
intracellular signal transduction
regulation of growth
fat cell differentiation
negative regulation of JAK-STAT cascade
cerebral cortex radially oriented cell migration
negative regulation of signal transduction
