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Rockland
SOD1 Polyclonal Antibody
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SOD1 Antibody (600-401-F20) in IHC (P)
Immunohistochemistry of rabbit anti-SOD1 antibody. Tissue: Syncytiotrophoblast of human placenta. Fixation: N/A. Primary Antibody: SOD1 antibody at 1 µg/mL for 1 hr at RT. Secondary antibody: Peroxidase rabbit secondary at 1:10,000 for 45 min at RT. Localization: Cytoplasm. Staining: SOD1 as precipitated brown signal.
产品信息
600-401-F20
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Dog,
Cnidarian,
Fish,
Hamster,
Human,
Invertebrate,
Mollusc,
Mouse,
Non-human primate,
Sheep,
Pig,
Rabbit,
Rat,
Xenopus
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
SOD1 Antibody was produced from whole rabbit serum prepared by repeated immunizations with a synthetic peptide corresponding to human SOD1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.1% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
SOD1 (superoxide dismutase) binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. This isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Amyotrophic lateral sclerosis 1 (ALS1); Cu(2+)-Zn2+ superoxide dismutase; Cu-Zn superoxide dismutase; Cu-Zn superoxide dismutase C-terminal fragment (150AA); Cu-Zn-superoxide dismutase; Cu/Zn SOD; Cu/Zn superoxide dismutase; CuZn superoxide dismutase; epididymis secretory protein Li 44; HGNC:11179; hSod1; indophenoloxidase A; Indophenoloxidase A (IPOA); SOD, soluble; superoxide dismutase; Superoxide dismutase 1; Superoxide Dismutase 1 (SOD1); superoxide dismutase 1 soluble; superoxide dismutase 1, soluble; superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)); superoxide dismutase 1, soluble S homeolog; Superoxide dismutase [Cu-Zn]; superoxide dismutase, cystolic
基因别名: ALS; ALS1; B430204E11Rik; Cu/Zn-SOD; CuZnSOD; HEL-S-44; homodimer; hSod1; Ipo-1; Ipo1; IPOA; SOD; Sod-1; SOD1; sod1-a; sod1-b; SOD1L1; SODC; XELAEV_18014289mg; xsodb
UniProt ID: (Pig) P04178, (Bovine) P00442, (Human) P00441, (Rabbit) P09212, (Dog) Q8WNN6, (Mouse) P08228, (Rat) P07632
superoxide dismutase activity
ubiquitin-protein transferase activity
copper ion binding
protein binding
zinc ion binding
protein phosphatase 2B binding
protein homodimerization activity
chaperone binding
identical protein binding
Rac GTPase binding
antioxidant activity
oxidoreductase activity
enzyme binding
metal ion binding
oxidoreductase
activation of MAPK activity
protein polyubiquitination
response to superoxide
ovarian follicle development
regulation of cytokine production
positive regulation of cytokine production
retina homeostasis
myeloid cell homeostasis
glutathione metabolic process
superoxide metabolic process
cellular iron ion homeostasis
spermatogenesis
embryo implantation
cell aging
sensory perception of sound
locomotory behavior
regulation of blood pressure
response to heat
response to organic substance
transmission of nerve impulse
removal of superoxide radicals
peripheral nervous system myelin maintenance
regulation of multicellular organism growth
response to drug
response to hydrogen peroxide
positive regulation of catalytic activity
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of neuron apoptotic process
interspecies interaction between organisms
response to ethanol
negative regulation of cholesterol biosynthetic process
regulation of protein kinase activity
muscle cell cellular homeostasis
response to axon injury
hydrogen peroxide biosynthetic process
positive regulation of nitric-oxide synthase biosynthetic process
regulation of mitochondrial membrane potential
oxidation-reduction process
heart contraction
neurofilament cytoskeleton organization
relaxation of vascular smooth muscle
auditory receptor cell stereocilium organization
reactive oxygen species metabolic process
response to reactive oxygen species
placenta development
response to amphetamine
platelet degranulation
anterograde axonal transport
retrograde axonal transport
response to nutrient levels
positive regulation of superoxide anion generation
regulation of T cell differentiation in thymus
response to carbon monoxide
cellular response to potassium ion
superoxide anion generation
positive regulation of apoptotic process
regulation of GTPase activity
regulation of organ growth
response to antibiotic
response to copper ion
thymus development
cellular response to cadmium ion
cellular response to ATP
response to antipsychotic drug
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
response to oxidative stress
aging
negative regulation of apoptotic process
double-strand break repair
apoptotic DNA fragmentation
cellular response to oxidative stress
