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Invitrogen
SOD1 Polyclonal Antibody
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SOD1 Antibody (PA5-18497) in ICC/IF
Immunocytochemistry analysis of SOD1 using SOD1 Polyclonal Antibody (Product # PA5-18497) in paraformaldehyde fixed U2OS cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing nuclear and cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL).
产品信息
PA5-18497
产品规格
种属反应
Human,
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (SRKHGGPKDEERH) corresponding to the internal amino acids of SOD1 (aa 69-81).
偶联物
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is predicted to react with canine based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 8,000.
靶标信息
SOD1 (superoxide dismutase) binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. This isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: amyotrophic lateral sclerosis 1; Amyotrophic lateral sclerosis 1 (ALS1); Cu(2+)-Zn2+ superoxide dismutase; Cu/Zn SOD; Cu/Zn superoxide dismutase; epididymis secretory protein Li 44; HGNC:11179; hSod1; Hydrogen sulfide oxidase; indophenoloxidase A; Indophenoloxidase A (IPOA); indophenoloxidase A; soluble; cystolic; Cu/Zn superoxide dismutase; epididymis secretory protein Li 44; SOD, soluble; SOD1; superoxide dismutase; Superoxide dismutase 1; Superoxide Dismutase 1 (SOD1); superoxide dismutase 1, soluble; Superoxide dismutase [Cu-Zn]; superoxide dismutase, cystolic; unnamed protein product
基因别名: ALS; ALS1; B430204E11Rik; Cu/Zn-SOD; CuZnSOD; HEL-S-44; homodimer; hSod1; Ipo-1; Ipo1; IPOA; SOD; Sod-1; SOD1; SODC; STAHP
UniProt ID: (Human) P00441, (Mouse) P08228
Entrez Gene ID: (Human) 6647, (Mouse) 20655
superoxide dismutase activity
copper ion binding
protein binding
zinc ion binding
antioxidant activity
oxidoreductase activity
enzyme binding
protein phosphatase 2B binding
small GTPase binding
identical protein binding
protein homodimerization activity
metal ion binding
chaperone binding
Rac GTPase binding
oxidoreductase
response to reactive oxygen species
response to superoxide
ovarian follicle development
positive regulation of cytokine production
placenta development
retina homeostasis
response to amphetamine
myeloid cell homeostasis
glutathione metabolic process
superoxide metabolic process
cellular iron ion homeostasis
apoptotic process
response to oxidative stress
spermatogenesis
embryo implantation
sensory perception of sound
locomotory behavior
anterograde axonal transport
retrograde axonal transport
regulation of blood pressure
determination of adult lifespan
response to heat
response to xenobiotic stimulus
gene expression
transmission of nerve impulse
neuronal action potential
removal of superoxide radicals
response to nutrient levels
peripheral nervous system myelin maintenance
positive regulation of superoxide anion generation
regulation of T cell differentiation in thymus
response to carbon monoxide
cellular response to oxidative stress
ectopic germ cell programmed cell death
cellular response to potassium ion
regulation of multicellular organism growth
response to hydrogen peroxide
superoxide anion generation
positive regulation of apoptotic process
negative regulation of apoptotic process
regulation of GTPase activity
positive regulation of MAPK cascade
negative regulation of neuron apoptotic process
response to ethanol
regulation of organ growth
response to copper ion
muscle cell cellular homeostasis
thymus development
response to axon injury
hydrogen peroxide biosynthetic process
negative regulation of inflammatory response
positive regulation of phagocytosis
negative regulation of developmental process
regulation of mitochondrial membrane potential
heart contraction
neurofilament cytoskeleton organization
relaxation of vascular smooth muscle
auditory receptor cell stereocilium organization
cellular response to cadmium ion
cellular response to ATP
reactive oxygen species metabolic process
response to antipsychotic drug
action potential initiation
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
negative regulation of reproductive process
activation of MAPK activity
aging
cell aging
response to organic substance
response to drug
positive regulation of catalytic activity
negative regulation of cholesterol biosynthetic process
regulation of protein kinase activity
oxidation-reduction process
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