Search Thermo Fisher Scientific
SOX2 is an intronless gene encoding a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of the SOX2 gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. The SOX2 gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). Further, SOX2 protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation, optic nerve hypoplasia and syndromic microphthalmia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Delta EF2a; MCOPS3 (Microphthalmia Syndromic type 3); SOX 2; SRY (sex determining region Y) box 2; SRY (sex determining region Y)-box 2; SRY related HMG box 2; SRY-box containing gene 2; Transcription factor Sox-2; transcription factor SOX2
基因别名: cb236; sox2; soxp; wu:fb83g04; wu:fc14d07; zgc:65860; zgc:77389
UniProt ID: (Zebrafish) Q6P0E1
Entrez Gene ID: (Zebrafish) 378723
分子生物学功能: HMG box transcription factor