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Product may be used with Western Blot (Cell lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MSSKQATSPF ACAADGEDAM TQDLTSREKE EGSDQHVASH LPLHPIMHNK PHSEELPTLV STIQQDADWD SVLSSQQRME SENNKLCSLY SFRNTSTSPH KPDEGSRDRE IMTSVTFGTP ERRKGSLADV VDTLKQKKLE EMTRTEQEDS SCMEKLLSKD WKEKMERLNT SELLGEIKGT PESLAEKERQ LSTMITQLIS LREQLLAAHD EQKKLAASQI EKQRQQMDLA RQQQEQIARQ QQQLLQQQHK INLLQQQIQV QGHMPPLMIP IFPHDQRTLA AAAAAQQGFL FPPGITYKPG DNYPVQFIPS TMAAAAASGL SPLQLQKGHV SHPQINQRLK GLSDRFGRNL DTFEHGGGHS YNHKQIEQLY AAQLASMQVS PGAKMPSTPQ PPNTAGTVSP TGIKNEKRGT SPVTQVKDEA AAQPLNLSSR PKTAEPVKSP TSPTQNLFPA SKTSPVNLPN KSSIPSPIGG SLGRGSSLDI LSSLNSPALF GDQDTVMKAI QEARKMREQI QREQQQQQPH GVDGKLSSIN NMGLNSCRNE KERTRFENLG PQLTGKSNED GKLGPGVIDL TRPEDAEGSK AMNGSAAKLQ QYYCWPTGGA TVAEARVYRD ARGRASSEPH IKRPMNAFMV WAKDERRKIL QAFPDMHNSN ISKILGSRWK SMSNQEKQPY YEEQARLSKI HLEKYPNYKY KPRPKRTCIV DGKKLRIGEY KQLMRSRRQE MRQFFTVGQQ PQIPITTGTG VVYPGAITMA TTTPSPQMTS DCSSTSASPE PSLPVIQSTY GMKTDGGSLA GNEMINGEDE MEMYDDYEDD PKSDYSSENE APEAVSAN
The SOX6 gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors, which are known to play vital roles in the regulation of developmental processes and cell fate determination. SOX6, along with its close relatives SOX5 and SOX13, constitutes the SOXD subfamily, which is involved in the regulation of the development of the central nervous system, skeletal system, and cartilage. It functions by binding to specific DNA sequences and modulating the expression of target genes necessary for these developmental processes. SOX6 has been implicated in various functions, such as promoting cartilage formation by acting in conjunction with SOX9 to drive chondrogenesis. In adult neural stem cells, SOX6 is essential for the activation of radial glial-like cells and the generation of new neurons, emphasizing its role in both embryonic development and adult tissue maintenance. The dysregulation of SOX6 has been associated with developmental disorders and its potential involvement in pathologies like cancer, where it influences cell differentiation and proliferation pathways.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: SRY (sex determining region Y)-box 6; SRY box 6; SRY-box containing gene 6; Transcription factor SOX-6
基因别名: HSSOX6; SOX6; SOXD
UniProt ID: (Human) Q9H0I8
Entrez Gene ID: (Human) 55553