Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
SOX6 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
产品信息
PA5-81994
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human SOX6. Recombinant protein control fragment (Product #RP-102022).
偶联物
形式
Liquid
浓度
0.09 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: TYKPGDNYPV QFIPSTMAAA AASGLSPLQL QQLYAAQLAS MQVSPGAKMP STPQPPNTAG TVSPTGIKNE KRGTSPVTQV KDEAAAQPLN LSSRPKTAEP VKSPTS
Highest antigen sequence indentity to the following orthologs: Rat - 96%, Mouse - 96%.
靶标信息
The SOX6 gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors, which are known to play vital roles in the regulation of developmental processes and cell fate determination. SOX6, along with its close relatives SOX5 and SOX13, constitutes the SOXD subfamily, which is involved in the regulation of the development of the central nervous system, skeletal system, and cartilage. It functions by binding to specific DNA sequences and modulating the expression of target genes necessary for these developmental processes. SOX6 has been implicated in various functions, such as promoting cartilage formation by acting in conjunction with SOX9 to drive chondrogenesis. In adult neural stem cells, SOX6 is essential for the activation of radial glial-like cells and the generation of new neurons, emphasizing its role in both embryonic development and adult tissue maintenance. The dysregulation of SOX6 has been associated with developmental disorders and its potential involvement in pathologies like cancer, where it influences cell differentiation and proliferation pathways.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: SRY (sex determining region Y)-box 6; SRY box 6; SRY-box containing gene 6; Transcription factor SOX-6
基因别名: HSSOX6; SOX6; SOXD
UniProt ID: (Human) Q9H0I8
Entrez Gene ID: (Human) 55553
negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
in utero embryonic development
transcription, DNA-templated
regulation of transcription, DNA-templated
muscle organ development
post-embryonic development
gene silencing
oligodendrocyte cell fate specification
positive regulation of chondrocyte differentiation
positive regulation of transcription from RNA polymerase II promoter
astrocyte differentiation
erythrocyte development
cartilage development
cardiac muscle cell differentiation
positive regulation of cartilage development
cellular response to transforming growth factor beta stimulus
negative regulation of cardiac muscle cell differentiation
positive regulation of mesenchymal stem cell differentiation
