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          Disclaimer

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • SOX8/SOX9/SOX17/SOX18 Antibodies

          Invitrogen

          SOX8/SOX9/SOX17/SOX18 Polyclonal Antibody

          查看其他2个SOX8/SOX9/SOX17/SOX18抗体

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          Cite SOX8/SOX9/SOX17/SOX18 Polyclonal Antibody

          • 抗体检测数据 (4)
          SOX8/SOX9/SOX17/SOX18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          SOX8/SOX9/SOX17/SOX18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          图: 1 / 4

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          SOX8/SOX9/SOX17/SOX18 Antibody (PA5-36315) in IHC (P)

          Immunohistochemistry analysis of SOX8/SOX9/SOX17/SOX18 in paraffin-embedded human colorectal carcinoma tissue. Samples were incubated with SOX8/SOX9/SOX17/SOX18 polyclonal antibody (Product # PA5-36315) at a dilution of 1:50. {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
          已发表图片由___提供 benchsci-logo
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          SOX8/SOX9/SOX17/SOX18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          SOX8/SOX9/SOX17/SOX18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          SOX8/SOX9/SOX17/SOX18 Antibody in Western Blot (WB)
          SOX8/SOX9/SOX17/SOX18 Antibody in Western Blot (WB)
          SOX8/SOX9/SOX17/SOX18 Polyclonal Antibody

          产品信息

          PA5-36315

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1:500-1:1,000
          -

          免疫组化(石蜡) (IHC (P))

          1:50-1:200
          -
          产品规格

          种属反应

          Human, Mouse, Rat

          宿主/亚型

          Rabbit / IgG

          分类

          Polyclonal

          类型

          Antibody

          抗原

          Synthetic peptide corresponding to amino acids 120-170 of human Sox8
          查看免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          1 mg/mL

          纯化类型

          Antigen affinity chromatography

          保存液

          PBS, pH 7.2

          内含物

          0.05% sodium azide

          保存条件

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          运输条件

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2553470

          产品详细信息

          This antibody detects endogenous protein at a molecular weight of 47 kDa.

          Purity is >95% by SDS-PAGE.

          靶标信息

          Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          篇参考文献 (0)

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          引用该产品

          生物信息学

          蛋白别名: mSox9; ragged; SRY (sex determining region Y)-box 17; SRY (sex determining region Y)-box 18; SRY (sex determining region Y)-box 8; SRY (sex determining region Y)-box 9; SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal); SRY (sex determining region Y)-box9; SRY (sex-determining region Y)-box 9 protein; SRY box 17; SRY box 18; SRY box 8; SRY box 9; SRY-box containing gene 17; SRY-box containing gene 18; SRY-box containing gene 8; SRY-box containing gene 9; Sry-related HMG-box gene 18; SRY-related HMG-box transcription factor SOX17; SRY-related HMG-box, gene 9; Transcription factor SOX-17; Transcription factor SOX-18; Transcription factor SOX-8; Transcription factor SOX-9

          查看更多 收起

          基因别名: 2010306G03Rik; AI385749; AV220920; CMD1; CMPD1; HLTRS; HLTS; mKIAA4243; Ra; Ragl; Sox-17; Sox-18; Sox-8; Sox-9; SOX17; SOX18; SOX8; SOX9; SRA1; SRXX2; SRXY10; VUR3

          查看更多 收起

          UniProt ID: (Human) Q9H6I2, (Human) P35713, (Human) P57073, (Human) P48436, (Mouse) Q61473, (Mouse) P43680, (Mouse) Q04886, (Rat) F1LYL9, (Mouse) Q04887

          查看更多 收起

          Entrez Gene ID: (Human) 64321, (Human) 54345, (Human) 30812, (Human) 6662, (Mouse) 20671, (Rat) 312936, (Rat) 311723, (Mouse) 20672, (Mouse) 20681, (Rat) 302993, (Rat) 140586, (Mouse) 20682

          查看更多 收起

          功能
          transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription coactivator activity protein binding beta-catenin binding transcription factor binding sequence-specific DNA binding transcription regulatory region DNA binding protein heterodimerization activity RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding core promoter sequence-specific DNA binding enhancer sequence-specific DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein kinase activity protein kinase A catalytic subunit binding enhancer binding bHLH transcription factor binding pre-mRNA intronic binding molecular_function transcription regulatory region sequence-specific DNA binding HMG box transcription factor
          参与通路
          negative regulation of transcription from RNA polymerase II promoter angiogenesis vasculogenesis endoderm formation inner cell mass cellular morphogenesis heart looping cardiogenic plate morphogenesis embryonic heart tube morphogenesis outflow tract morphogenesis negative regulation of Wnt signaling pathway involved in heart development regulation of transcription, DNA-templated spermatogenesis endodermal cell fate determination rostrocaudal neural tube patterning signal transduction involved in regulation of gene expression negative regulation of cell growth protein destabilization embryonic heart tube development cell migration involved in gastrulation negative regulation of mesodermal cell fate specification mRNA transcription from RNA polymerase II promoter positive regulation of cell differentiation positive regulation of protein catabolic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of embryonic development embryonic foregut morphogenesis positive regulation of skeletal muscle tissue development stem cell fate specification protein stabilization canonical Wnt signaling pathway endocardium formation regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification cardiac cell fate determination heart formation endocardial cell differentiation common bile duct development gall bladder development endodermal digestive tract morphogenesis renal system development regulation of stem cell proliferation negative regulation of canonical Wnt signaling pathway regulation of stem cell division regulation of cardiac cell fate specification in utero embryonic development hair follicle development vasculature development lymphangiogenesis hair cycle process blood vessel endothelial cell migration negative regulation of transcription, DNA-templated cell maturation lymphatic endothelial cell differentiation establishment of endothelial barrier osteoblast differentiation neural crest cell migration transcription, DNA-templated signal transduction peripheral nervous system development male gonad development regulation of hormone levels positive regulation of gliogenesis positive regulation of osteoblast proliferation skeletal muscle cell differentiation negative regulation of apoptotic process cell fate commitment fat cell differentiation negative regulation of myoblast differentiation negative regulation of photoreceptor cell differentiation enteric nervous system development oligodendrocyte differentiation Sertoli cell development astrocyte fate commitment retina development in camera-type eye retinal rod cell differentiation adipose tissue development morphogenesis of a branching epithelium renal vesicle induction ureter morphogenesis metanephric nephron tubule formation positive regulation of kidney development positive regulation of branching involved in ureteric bud morphogenesis skeletal system development cartilage condensation ossification branching involved in ureteric bud morphogenesis cell fate specification epithelial to mesenchymal transition tissue homeostasis positive regulation of protein phosphorylation positive regulation of mesenchymal cell proliferation negative regulation of immune system process heart valve development heart valve morphogenesis heart valve formation endocardial cushion morphogenesis chondrocyte differentiation involved in endochondral bone morphogenesis chondrocyte hypertrophy nucleosome assembly chromatin remodeling transcription from RNA polymerase II promoter protein complex assembly cytoskeleton organization epidermal growth factor receptor signaling pathway Notch signaling pathway positive regulation of cell proliferation regulation of cell cycle process positive regulation of epithelial cell migration neural crest cell development positive regulation of phosphatidylinositol 3-kinase signaling single organismal cell-cell adhesion male germ-line sex determination cAMP-mediated signaling regulation of cell adhesion extracellular matrix organization negative regulation of ossification negative regulation of bone mineralization prostate gland development negative regulation of epithelial cell differentiation positive regulation of epithelial cell differentiation mammary gland development notochord development otic vesicle formation endocrine pancreas development negative regulation of chondrocyte differentiation positive regulation of chondrocyte differentiation lacrimal gland development protein localization to nucleus somatic stem cell population maintenance intrahepatic bile duct development regulation of cell proliferation regulation of apoptotic process protein kinase B signaling positive regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation cartilage development Sertoli cell differentiation limb bud formation epithelial tube branching involved in lung morphogenesis lung epithelial cell differentiation epithelial cell proliferation involved in prostatic bud elongation bronchus cartilage development trachea cartilage development intestinal epithelial structure maintenance regulation of cell proliferation involved in tissue homeostasis positive regulation of cartilage development regulation of branching involved in lung morphogenesis lung smooth muscle development negative regulation of biomineral tissue development ERK1 and ERK2 cascade Harderian gland development cellular response to mechanical stimulus cellular response to retinoic acid cellular response to interleukin-1 cellular response to epidermal growth factor stimulus cellular response to heparin cellular response to transforming growth factor beta stimulus ureter urothelium development ureter smooth muscle cell differentiation cochlea morphogenesis positive regulation of extracellular matrix assembly positive regulation of male gonad development positive regulation of cell proliferation involved in heart morphogenesis positive regulation of mesenchymal stem cell differentiation regulation of epithelial cell proliferation involved in lung morphogenesis negative regulation of mesenchymal cell apoptotic process gastrulation endoderm development positive regulation of gene expression Wnt signaling pathway negative regulation of Wnt signaling pathway regulation of mesodermal cell fate specification regulation of cell differentiation embryonic organ development stem cell differentiation biological_process blood vessel development lymph vessel development regulation of transcription from RNA polymerase II promoter heart development chondrocyte development protein phosphorylation negative regulation of cell proliferation negative regulation of gene expression cell differentiation male sex determination homeostasis of number of cells within a tissue endochondral bone morphogenesis prostate gland morphogenesis ureter development
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