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This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Transcription factor Sp2
基因别名: KIAA0048; SP2
UniProt ID: (Human) Q02086
Entrez Gene ID: (Human) 6668