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Invitrogen
SPIN1 Polyclonal Antibody
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FIGURE: 1 / 3
SPIN1 Antibody (PA5-96448) in IHC (P)
Immunohistochemistry analysis of SPIN1 in paraffin-embedded mouse brain. Samples were incubated with SPIN1 Polyclonal antibody (Product # PA5-96448) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-96448
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-262 of human SPIN1 (NP_0067082)
Conjugate
Form
Liquid
Concentration
0.82 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MKTPFGKTPG QRSRADAGHA GVSANMMKKR TSHKKHRSSV GPSKPVSQPR RNIVGCRIQH GWKEGNGPVT QWKGTVLDQV PVNPSLYLIK YDGFDCVYGL ELNKDERVSA LEVLPDRVAT SRISDAHLAD TMIGKAVEHM FETEDGSKDE WRGMVLARAP VMNTWFYITY EKDPVLYMYQ LLDDYKEGDL RIMPDSNDSP PAEREPGEVV DSLVGKQVEY AKEDGSKRTG MVIHQVEAKP SVYFIKFDDD FHIYVYDLVK TS; Positive Samples: MCF7, SW480, 293T, Jurkat, HeLa, HepG2, SH-SY5Y, Mouse brain; Cellular Location: Nucleus, nucleolus
Target Information
SPIN1 (spindlin 1), also known as SPIN or ovarian cancer-related protein (OCR), is a 262 amino acid nuclear protein suggested to play a role in regulation of the cell-cycle during the transition from gamete to embryo. A member of the SPIN/STSY family, SPIN1 localizes to interphase nucleus and mitotic chromosomes, and is modified by phosphorylation in a cell-cycle-dependent fashion. A meiotic spindle-binding protein, SPIN1 overexpression has been shown to cause defects in mitotic spindles, thereby resulting in chromosome instability and potential tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 30000 Mr metaphase complex; ovarian cancer-related (OCR) protein; Ovarian cancer-related protein; SPIN; Spindlin-1; Spindlin1; SSEC P; unnamed protein product
Gene Aliases: OCR; SPIN; SPIN1; TDRD24
UniProt ID: (Human) Q9Y657, (Mouse) Q61142, (Rat) Q4V8J7
Entrez Gene ID: (Human) 10927, (Mouse) 20729, (Rat) 361217
cell cycle
female meiotic division
multicellular organism development
gamete generation
rRNA transcription
Wnt signaling pathway
chromatin modification
positive regulation of Wnt signaling pathway
meiotic cell cycle
chromatin organization
regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
protein localization to chromatin
transposable element silencing by piRNA-mediated DNA methylation
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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