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Invitrogen
SPINK1 Polyclonal Antibody
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SPINK1 Antibody (PA5-102353) in ICC/IF
Immunocytochemistry analysis of SPINK1 in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with SPINK1 polyclonal antibody (Product # PA5-102353) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
产品信息
PA5-102353
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human SPINK1(Accession P00995), corresponding to amino acid residues L14-N64.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total SPINK1.
靶标信息
This is a trypsin inhibitor, its physiological function is to prevent the trypsin-catalyzed premature activation of zymogens within the pancreas. Defects in SPINK1 are a cause of pancreatitis (PCTT) [MIM:167800]. A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks. Defects in SPINK1 are the cause of susceptibility to tropical calcific pancreatitis (TCP) [MIM:608189]. TCP is an idiopathic, juvenile, nonalcoholic form of chronic pancreatitis widely prevalent in several tropical countries. It can be associated with fibrocalculous pancreatic diabetes (FCPD) depending on both environmental and genetic factors. TCP differs from alcoholic pancreatitis by a much younger age of onset, pancreatic calcification, a high incidence of insulin dependent but ketosis resistant diabetes mellitus, and an exceptionally high incidence of pancreatic cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Calcium transport inhibitor; Caltrin; ISK1; P12; Pancreatic secretory trypsin inhibitor; Pancreatic secretory trypsin inhibitor II; pancreatic secretory trypsin inhibitor type II (PSTI-II); Prostatic secretory glycoprotein; PSTI-II; serine peptidase inhibitor, Kazal type 3; Serine protease inhibitor Kazal-type 1; Serine protease inhibitor Kazal-type 1-like; Serine protease inhibitor Kazal-type 3; serine protease inhibitor, Kazal type 1; serine protease inhibitor, Kazal type 3; Spink 3; TATI; Tumor-associated trypsin inhibitor
基因别名: p12; PCTT; PSTI; SPINK1; Spink1l; Spink3; TATI; TCP
UniProt ID: (Human) P00995, (Mouse) P09036, (Rat) P09656
Entrez Gene ID: (Human) 6690, (Mouse) 20730, (Rat) 266602
negative regulation of nitric oxide mediated signal transduction
negative regulation of peptidyl-tyrosine phosphorylation
regulation of acrosome reaction
negative regulation of calcium ion import
negative regulation of serine-type endopeptidase activity
regulation of store-operated calcium entry
negative regulation of peptidase activity
negative regulation of endopeptidase activity
