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Agrisera
SQE1-3/Squalene epoxidase1-3 Polyclonal Antibody
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SQE1-3/Squalene epoxidase1-3 Antibody (AS22-4820) in WB
Samples: 1 - 20 µg of Withania somnifera whole leaf extract (leaves) – adult plant, in soil, full watering 2 - 20 µg of Withania somnifera whole leaf extract (leaves) – adult plant, in soil, drought treatment 3 - 20 µg of Withania somnifera whole leaf extract (leaves) – adult plant, in soil, yeast extract treatment 4 – No samples 5 - 20 µg of Arabidopsis thaliana whole leaf extract (leaves) – rosette develo... View More
产品信息
AS22-4820
产品规格
种属反应
Plant
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
KLH-conjugated peptide derived from Arabidopsis thaliana SQE protein sequences.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
规格
50 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.
For reconstitution add 50 µL of sterile water.
Specific Species Reactivity: Arabidopsis thaliana
靶标信息
In Arabidopsis thaliana, SQE1, SQE2, and SQE3 encode closely related squalene epoxidases that are associated with endomembranes and catalyze the oxygenation of squalene to 2,3-oxidosqualene, a key gateway metabolite for cyclic triterpenoid production. SQE3 (a multi-exon gene) and SQE1 proteins localize to the endoplasmic reticulum, consistent with their role in channeling flux through sterol and brassinosteroid biosynthesis, while SQE2 is also enzymatically competent in heterologous assays but appears to contribute less to bulk squalene epoxidase activity in planta. Genetic evidence indicates these enzymes are only partially redundant: loss of SQE1 causes strong developmental phenotypes (including reduced root and hypocotyl elongation and defective seed development) and leads to squalene accumulation, demonstrating that SQE1 activity is essential for normal growth; SQE3 can functionally complement SQE1 and is particularly important for embryo development, whereas SQE2 does not compensate to the same extent. Collectively, SQE1-3 form a core enzymatic module in the mevalonate-derived isoprenoid pathway that supports membrane sterol homeostasis and downstream signaling/metabolic outputs dependent on oxidosqualene-derived triterpenoids.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: squalene epoxidase 3; T28I19.40; T28I19_40
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