Search Thermo Fisher Scientific
Invitrogen
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
Immunogen sequence: ELHAPLTVVA DGLFSKFRKS LVSNKVSVSS HFVGFLMKNA PQFKANHAEL ILANPSPVLI YQISSSETRV LVDIRGEMPR NLREYMVEKI YPQIPDHLKE PFLEATDNSH LRSMPASFLP PSSVKKRGVL LLGDA
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 86%.
SQLE, also named as ERG1, SE and SM, belongs to the squalene monooxygenase family. It catalyzes the first oxygenation step in cholesterol synthesis, acting on squalene before cyclization into the basic steroid structure. SQLE may serve as a flux-controlling enzyme beyond 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR, considered as rate limiting). It is also post translationally regulated by cholesterol-dependent proteasomal degradation. The MW of SQLE is about 64 kDa.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: FLJ30795; SE; Squalene epoxidase; Squalene monooxygenase
基因别名: ERG1; SQLE
UniProt ID: (Human) Q14534
Entrez Gene ID: (Human) 6713