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Invitrogen
SRD5A2 Polyclonal Antibody
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SRD5A2 Antibody (PA5-115961) in IHC (P)
Immunohistochemistry analysis of SRD5A2 in mouse testis tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115961) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-115961
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human SRD5A2(Accession P31213), corresponding to amino acid residues M1-G32.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total SRD5A2.
靶标信息
This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 5 alpha-SR2; MGC138457; S5AR 2; SR type 2; steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2); type II 5-alpha reductase; unnamed protein product
UniProt ID: (Human) P31213
Entrez Gene ID: (Human) 6716
lipid metabolic process
steroid biosynthetic process
androgen biosynthetic process
steroid catabolic process
cell-cell signaling
steroid metabolic process
androgen metabolic process
male gonad development
response to xenobiotic stimulus
dibenzo-p-dioxin metabolic process
phthalate metabolic process
hippocampus development
hypothalamus development
male genitalia development
female genitalia development
response to nutrient levels
response to follicle-stimulating hormone
response to testosterone
response to peptide hormone
response to steroid hormone
bone development
testosterone biosynthetic process
response to biphenyl
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