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Abnova
SRF Monoclonal Antibody (1C8)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00006722-M02
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
1C8
抗原
SRF (AAH48211, 406 a.a. approximately 508 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: HMMYPSPHAV MYAPTSGLGD GSLTVLNAFS QAPSTMQVSH SQVQEPGGVP QVFLTASSGT VQIPVSAVQL HQMAVIGQQA GSSSNLTELQ VVNLDTAHST KSE
靶标信息
Serum response factor (SRF) is a transcription factor that binds the serum response element (SRE), a sequence that mediates the transient response of many cellular genes to growth stimulation. SRF-binding sites are also constitutive promotor elements in many muscle-specific promotors. SFR is required for cardiac differentiation and maturation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: c-fos serum response element-binding transcription factor; minichromosome maintenance 1 homolog; OTTHUMP00000039820; serum response factor; unnamed protein product
基因别名: MCM1
UniProt ID: (Human) P11831
Entrez Gene ID: (Human) 6722
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
serum response element binding
chromatin DNA binding
protein homodimerization activity
histone deacetylase binding
sequence-specific DNA binding
protein dimerization activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
primary miRNA binding
DNA-binding transcription factor binding
sequence-specific double-stranded DNA binding
response to hypoxia
in utero embryonic development
trophectodermal cell differentiation
heart looping
cell migration involved in sprouting angiogenesis
heart development
long-term memory
negative regulation of cell proliferation
response to toxic substance
response to hormone
actin cytoskeleton organization
negative regulation of cell migration
response to cytokine
wound healing
positive regulation of cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of smooth muscle contraction
positive regulation of transcription by glucose
muscle cell cellular homeostasis
neuron development
regulation of smooth muscle cell differentiation
angiogenesis involved in wound healing
positive regulation of transcription initiation from RNA polymerase II promoter
cardiac muscle cell myoblast differentiation
cellular response to glucose stimulus
cellular senescence
negative regulation of beta-amyloid clearance
negative regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
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