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          • Primary Antibodies ›
          • STAT5 alpha/beta Antibodies

          Invitrogen

          STAT5 alpha/beta Recombinant Rabbit Monoclonal Antibody (K01_4U20)

          查看其他14个STAT5 alpha/beta抗体

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          Cite STAT5 alpha/beta Recombinant Rabbit Monoclonal Antibody (K01_4U20)

          Additional Information:
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          • 抗体检测数据 (3)
          STAT5 alpha/beta Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          STAT5 alpha/beta Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          图: 1 / 3

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          STAT5 alpha/beta Antibody (MA567803) in IHC (P)

          Immunohistochemical (Paraffin) analysis of STAT5 alpha/beta in Human breast using STAT5 alpha/beta Recombinant Monoclonal Antibody (Product # MA567803). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval. {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
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          STAT5 alpha/beta Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          STAT5 alpha/beta Antibody in Western Blot (WB)
          STAT5 alpha/beta Antibody in Immunoprecipitation (IP)

          产品信息

          MA567803

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1:1,000
          -

          免疫组化(石蜡) (IHC (P))

          1:50-1:100
          -

          免疫沉淀 (IP)

          1:1,000
          -
          产品规格

          种属反应

          Human, Mouse, Rat

          宿主/亚型

          Rabbit / IgG

          Expression System

          HEK293F

          分类

          Recombinant Monoclonal

          类型

          Antibody

          克隆号

          K01_4U20

          抗原

          A synthesized peptide derived from human STAT5A/B.

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          1 mg/mL

          纯化类型

          Protein A/G

          保存液

          PBS, pH 7.4, with 50% glycerol, 150mM NaCl, 0.05% BSA

          内含物

          0.02% sodium azide

          保存条件

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          运输条件

          Ambient (domestic); Wet ice (international)

          靶标信息

          The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of, many cell ligands, such as IL-2, IL-3, IL-7, GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/ BCL-X(L), which suggests the antiapoptotic function of this gene in cells.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          篇参考文献 (0)

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          引用该产品

          生物信息学

          蛋白别名: epididymis secretory sperm binding protein; Mammary gland factor; mammary gland factor STAT5A; mammary gland factor STAT5B; signal transducer and activator of transcription 5; Signal transducer and activator of transcription 5A; Signal transducer and activator of transcription 5B; STA5B; STAT; transcription factor STAT5B; unnamed protein product

          查看更多 收起

          基因别名: AA959963; GHISID2; MGF; Mpf; STAT5; STAT5A; STAT5B

          查看更多 收起

          UniProt ID: (Human) P42229, (Human) P51692, (Rat) Q62771, (Mouse) P42230, (Rat) P52632, (Mouse) P42232

          查看更多 收起

          Entrez Gene ID: (Human) 6776, (Human) 6777, (Rat) 24918, (Mouse) 20850, (Rat) 25126, (Mouse) 20851

          查看更多 收起

          功能
          RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding phosphate ion binding sequence-specific DNA binding DNA-binding transcription factor binding chromatin binding glucocorticoid receptor binding identical protein binding protein homodimerization activity protein dimerization activity RNA polymerase II core promoter sequence-specific DNA binding double-stranded DNA binding signal transducer activity protein phosphatase binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA-binding transcription factor
          参与通路
          mitotic cell cycle luteinization natural killer cell differentiation positive regulation of endothelial cell proliferation regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter defense response signal transduction JAK-STAT cascade female pregnancy lactation cell proliferation positive regulation of cell proliferation regulation of steroid metabolic process cytokine-mediated signaling pathway taurine metabolic process lipid storage lymphocyte differentiation regulation of cell adhesion B cell differentiation erythrocyte differentiation eosinophil differentiation regulation of epithelial cell differentiation mammary gland development positive regulation of interleukin-2 production positive regulation of natural killer cell differentiation mast cell apoptotic process negative regulation of mast cell apoptotic process myeloid cell apoptotic process negative regulation of myeloid cell apoptotic process T cell differentiation in thymus interleukin-15-mediated signaling pathway interleukin-4-mediated signaling pathway reelin-mediated signaling pathway interleukin-5-mediated signaling pathway interleukin-2-mediated signaling pathway interleukin-7-mediated signaling pathway interleukin-9-mediated signaling pathway interleukin-3-mediated signaling pathway thrombopoietin-mediated signaling pathway regulation of multicellular organism growth positive regulation of multicellular organism growth T cell proliferation positive regulation of T cell proliferation positive regulation of activated T cell proliferation regulation of cell proliferation natural killer cell mediated cytotoxicity gamma-delta T cell differentiation T cell homeostasis response to peptide hormone positive regulation of blood vessel endothelial cell migration positive regulation of B cell differentiation positive regulation of gamma-delta T cell differentiation positive regulation of lymphocyte differentiation negative regulation of erythrocyte differentiation positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter positive regulation of natural killer cell mediated cytotoxicity development of secondary female sexual characteristics development of secondary male sexual characteristics Peyer's patch development positive regulation of inflammatory response activated T cell proliferation mast cell differentiation positive regulation of mast cell differentiation JAK-STAT cascade involved in growth hormone signaling pathway prostate gland epithelium morphogenesis epithelial cell differentiation involved in prostate gland development mammary gland epithelium development mast cell proliferation positive regulation of mast cell proliferation cellular response to granulocyte macrophage colony-stimulating factor stimulus regulation of hemopoiesis negative regulation of T-helper 17 cell lineage commitment natural killer cell proliferation sex differentiation response to estradiol positive regulation of natural killer cell proliferation cellular response to hormone stimulus erythropoietin-mediated signaling pathway progesterone metabolic process positive regulation of erythrocyte differentiation response to interleukin-2 response to interleukin-4 response to interleukin-15 cellular response to growth factor stimulus cellular response to epidermal growth factor stimulus mast cell migration allantoin metabolic process citrate metabolic process 2-oxoglutarate metabolic process succinate metabolic process oxaloacetate metabolic process transcription, DNA-templated isoleucine metabolic process valine metabolic process creatine metabolic process fatty acid metabolic process peptidyl-tyrosine phosphorylation response to nutrient levels prolactin signaling pathway negative regulation of apoptotic process positive regulation of interleukin-2 biosynthetic process response to ethanol creatinine metabolic process multicellular organismal reproductive process mammary gland involution response to hypoxia liver development acute-phase response response to lipopolysaccharide positive regulation of smooth muscle cell proliferation positive regulation of cellular component movement
          It has to be done as per old AB suggested Products section.

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