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Abnova
STIM1 Monoclonal Antibody (5A2)
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产品信息
H00006786-M01J
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
5A2
抗原
STIM1 (AAH21300, 24 a.a. approximately 685 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: SHSHSEKATG TSSGANSEES TAAEFCRIDK PLCHSEDEKL SFEAVRNIHK LMDDDANGDV DVEESDEFLR EDLNYHDPTV KHSTFHGEDK LISVEDLWKA WKSSEVYNWT VDEVVQWLIT YVELPQYEET FRKLQLSGHA MPRLAVTNTT MTGAVLKMTD RSHRQKLQLK ALDTVLFGPP LLTRHNHLKD FMLVVSIVIG VGGCWFAYIQ NRYSKEHMKK MMKDLEGLHR AEQSLHDLQE RLHKAQEEHR TVEVEKVHLE KKLRDEINLA KQEAQRLKEL REGTENERSR QKYAEEELEQ VREALRKAEK ELESHSSWYA PEALQKWLQL THEVEVQYYN IKKQNAEKQL LVAKEGAEKI KKKRNTLFGT FHVAHSSSLD DVDHKILTAK QALSEVTAAL RERLHRWQQI EILCGFQIVN NPGIHSLVAA LNIDPSWMGS TRPNPAHFIM TDDVDDMDEE IVSPLSMQSP SLQSSVRQRL TEPQHGLGSQ RDLTHSDSES SLHMSDRQRV APKPPQMSRA ADEALNAMTS NGSHRLIEGV HPGSLVEKLP DSPALAKKAL LALNHGLDKA HSLMELSPSA PPGGSPHLDS SRSHSPSSPD PDTPSPVGDS RALQASRNTR IPHLAGKKAV AEEDNGSIGE ETDSSPGRKK FPLKIFKKPL KK
Cell culture grade monoclonal antibodies are obtained by purifying "hybridoma culture medium" which completely eliminates any contamination of mice. They have high affinity, high purity, and no contamination.
靶标信息
STIM1 (stromal interacting molecule; also known as GOK) acts as a sensor of calcium depletion within the endoplasmic reticulum and transduces the signal to Orai1, the presumptive CRAC channel at the plasma membrane. Following decrease of luminal calcium concentration, STIM1 oligomerizes and induces Orai1 to enable entry of extracellular calcium into the cytoplasm. However, the precise mechanism of STIM1-Orai1 interaction has not been elucidated yet. Many questions also remain to be solved around STIM1 functional distribution. It turns out that STIM1 associates with growing ends of microtubules and is involved in endoplasmic reticulum tubule extension.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: STIM1L; Stromal interaction molecule 1
基因别名: D11S4896E; GOK; IMD10; STIM1; STRMK; TAM; TAM1
UniProt ID: (Human) Q13586
Entrez Gene ID: (Human) 6786
