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Abnova
STRADA Polyclonal Antibody, MaxPab™
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产品信息
H00092335-D01P
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
STRADA (NP_699166.2, 1 a.a. approximately 348 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Tissue lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MSFLTNDASS ESIASFSKQE VMSSFLPEGG CYELLTVIGK GFEDLMTVNL ARYKPTGEYV TVRRINLEAC SNEMVTFLQG ELHVSKLFNH PNIVPYRATF IADNELWVVT SFMAYGSAKD LICTHFMDGM NELAIAYILQ GVLKALDYIH HMGYVHRSVK ASHILISVDG KVYLSGLRSN LSMISHGQRQ RVVHDFPKYS VKVLPWLSPE VLQQNLQGYD AKSDIYSVGI TACELANGHV PFKDMPATQM LLEKLNGTVP CLLDTSTIPA EELTMSPSRS VANSGLSDSL TTSTPRPSNG DSPSHPYHRT FSPHFHHFVE QCLQRNPDAR YPCWPGPGLR ESRGCSGG
靶标信息
LYK5; STE20-related Adaptor Protein (STRAD); FLJ90524. Gene Map Locus is 17q23.3 and members of STE-20 like kinase family are known to stimulate MAPK pathways by directly activating MAPKKK. STRAD is a novel pseudokinase member of this family consisting of a STE-20 like kinase domain but lacks several residues that are required for its catalytic activity. It specifically binds LKB1 and plays a key role in regulating tumor suppressor activities of LKB1. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. STRAD-LKB1 interaction results in phosphorylation of STRAD and enhanced autophosphorylation of LKB1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: protein kinase LYK5; Serologically defined breast cancer antigen NY-BR-96; STE20-like pseudokinase; STE20-related adapter protein; STE20-related kinase adapter protein alpha; STRAD alpha
基因别名: LYK5; NY-BR-96; PMSE; Stlk; STRAD; STRADA
UniProt ID: (Human) Q7RTN6
Entrez Gene ID: (Human) 92335
