Invitrogen

STRAP Polyclonal Antibody

Name: STRAP Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-95249

查看其他10个STRAP抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (2)

STRAP Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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STRAP Antibody (PA5-95249) in IHC (P)

Immunohistochemistry analysis of STRAP in paraffin-embedded human mammary cancer tissue. Samples were incubated with STRAP polyclonal antibody (Product # PA5-95249).

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Immunogen image

Immunogen Image STRAP Polyclonal Antibody

产品信息

PA5-95249

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.1-0.5 µg/mL

免疫组化（石蜡） (IHC (P))

0.5-1 µg/mL

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide corresponding to a sequence at the N-terminus of human Unrip (78-104aa AADFTAKVWDAVSGDELMTLAHKHIVK).

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

500 µg/mL

纯化类型

Affinity chromatography

保存液

PBS with 5mg BSA

内含物

0.05mg sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

AB_2807053

产品详细信息

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: human HEK293 whole cell, human Jurkat whole cell, human PC-3 whole cell, human THP-1 whole cell, rat brain tissue, mouse HEPA1-6 whole cell, mouse RAW2467 whole cell. IHC: human mammary cancer tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

靶标信息

STRAP is a 350 amino acid MAP activator with WD-40 repeats that is localized both in the cytoplasm and the nucleus. It is a ubiquitously expressed protein that acts as an inhibitor of TGF-beta signaling and an important regulator of cell proliferation. Stable expression of STRAP results in activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and in down-regulation of the cyclin-dependent kinase inhibitor p21 (Cip1), which results in retinoblastoma protein hyperphosphorylation. Upregulation of STRAP might play a role in tumor development as an early event for colorectal cancers. It is the first component of the U snRNP assembly machinery that associates with SMN complex in a compartment-specific way and plays a crucial role in the intracellular distribution of SMN1.

仅用于科研。不用于诊断过程。未经明确授权不得转售。