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Invitrogen
STRO-1 Monoclonal Antibody (STRO-1), APC
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产品信息
MA5-28635
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rabbit,
Rat
已发表种属
C. elegans,
Human
宿主/亚型
Mouse
/ IgM, lambda
分类
Monoclonal
类型
Antibody
克隆号
STRO-1
抗原
Human CD34 positive bone marrow cells
偶联物
激发/发射光谱
651/660 nm
查看光谱
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Size-exclusion chromatography
保存液
TBS, pH 8, with 0.2% BSA
内含物
15mM sodium azide
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody recognizes an extracellular epitope of the cell surface antigen STRO-1 expressed by bone marrow mesenchymal stromal cells and nucleated erythroid precursors, but not by committed hematopoietic progenitors.
靶标信息
STRO-1 is a cell surface antigen expressed by stromal elements in human bone marrow. STRO-1 binds to approximately 10% of bone marrow mononuclear cells, greater than 95% of which are nucleated erythroid precursors, but does not react with committed progenitor cells (colony-forming unit granulocyte-macrophage (CFU-GM), erythroid bursts (BFU-E), and mixed colonies (CFU-Mix). From bone marrow cells, the frequency of fibroblast colony forming cells (CFU-F) is enriched approximately 100-fold in the STRO-1-positive/Glycophorin A-negative population than in the STRO-1-positive/Glycophorin A-positive population. When plated under long-term BM culture conditions, STRO-1-positive cells generate adherent cell layers containing multiple stromal cell types, including adipocytes, smooth muscle cells, and fibroblastic elements. A STRO-1-positive enriched subset of marrow cells is capable of differentiating into multiple mesenchymal lineages including hematopoiesis-supportive stromal cells with a vascular smooth muscle-like phenotype, adipocytes, osteoblasts and chondrocytes. STRO-1 is a valuable antibody for the identification, isolation and functional characterization of human bone marrow stromal cell precursors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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