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Invitrogen
SUMO4 Recombinant Rabbit Monoclonal Antibody (4H11)
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SUMO4 Antibody (MA572574) in WB
Western blot analysis of SUMO4 in HEK-293T and Jurkat lysates (25 µg/lane). Samples were incubated with SUMO4 Recombinant Monoclonal (Product # MA572574) at 1:1,000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at room temperature for 60 min.
产品信息
MA572574
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
4H11
抗原
KLH conjugated synthetic peptide derived from human SUMO 4.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.17 mg/mL
规格
17 µg
纯化类型
Protein A
保存液
TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
SUMO4 is a member of the SUMO gene family. This family of small ubiquitin-related modifiers covalently modify target lysines in proteins and control the target proteins' subcellular localization, stability, or activity. Upon oxidative stress, SUMO4 conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. This protein may also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to SUMO4 substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. In contrast to SUMO1, SUMO2 and SUMO3, SUMO4 seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates. SUMO4 is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. The M55V substitution has been associated with type I diabetes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: insulin-dependent diabetes mellitus 5; small ubiquitin-like modifier 4 protein; Small ubiquitin-like protein 4; Small ubiquitin-related modifier 4; SMT3 suppressor of mif two 3 homolog 2; SMT3 suppressor of mif two 3 homolog 4; SUMO 4; SUMO-4; SUMO4; small ubiquitin-like modifier
基因别名: dJ281H8.4; IDDM5; SMT3H4; SUMO-4; SUMO4
UniProt ID: (Human) Q6EEV6
Entrez Gene ID: (Human) 387082
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