Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
SUPV3L1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
产品信息
PA5-97306
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 577-786 of human SUPV3L1 (NP_0031622)
偶联物
形式
Liquid
浓度
1.07 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: APINKKQPFV CSSLLQFARQ YSRNEPLTFA WLRRYIKWPL LPPKNIKDLM DLEAVHDVLD LYLWLSYRFM DMFPDASLIR DLQKELDGII QDGVHNITKL IKMSETHKLL NLEGFPSGSQ SRLSGTLKSQ ARRTRGTKAL GSKATEPPSP DAGELSLASR LVQQGLLTPD MLKQLEKEWM TQQTEHNKEK TESGTHPKGT RRKKKEPDSD; Positive Samples: K-562, Raji, Jurkat, SW620, Mouse heart, Mouse kidney, Mouse liver; Cellular Location: Mitochondrion matrix, Nucleus, mitochondrion nucleoid
靶标信息
Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: ATP-dependent RNA helicase SUPV3L1, mitochondrial; Suppressor of var1 3-like protein 1; suppressor of var1, 3-like 1; suppressor of var1, 3-like 1(SUV3); SUV3-like helicase; SUV3-like protein 1
基因别名: 6330443E10Rik; SUPV3L1; SUV3; Suv3l1
UniProt ID: (Human) Q8IYB8, (Mouse) Q80YD1, (Rat) Q5EBA1
Entrez Gene ID: (Human) 6832, (Mouse) 338359, (Rat) 294385
DNA binding
DNA helicase activity
RNA binding
double-stranded RNA binding
ATP-dependent RNA helicase activity
helicase activity
protein binding
ATP binding
3'-5' RNA helicase activity
protein homodimerization activity
poly(A) RNA binding
nucleotide binding
hydrolase activity
hydrolase activity, acting on acid anhydrides
DNA metabolism protein
mitochondrial mRNA catabolic process
positive regulation of mitochondrial RNA catabolic process
mitochondrial RNA 3'-end processing
DNA recombination
RNA catabolic process
positive regulation of cell growth
DNA duplex unwinding
mitochondrial ncRNA surveillance
mitochondrial mRNA surveillance
negative regulation of apoptotic process
mitochondrion morphogenesis
chromatin maintenance
mitochondrial RNA surveillance
