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Antibodies Inc
Shank1 Monoclonal Antibody (N22/21), FL594
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产品信息
75-064-FL594
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
N22/21
抗原
Fusion protein amino acids 469-691 (SH3/PDZ domains) of rat Shank1 (accession number Q9WV48) produced recombinantly in E. Coli.
偶联物
激发/发射光谱
594/615 nm
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Dry ice (international)
产品详细信息
For maximum recovery of product, centrifuge the vial prior to removing the cap.
靶标信息
Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GKAP/SAPAP interacting protein; GKAP/SAPAP-interacting protein; OTTHUMP00000174437; SAPAP-interacting protein synamon; SH3 and multiple ankyrin repeat domains 1; SH3 and multiple ankyrin repeat domains protein 1; SH3/ankyrin domain gene 1; SHANK 1; Shank1; Somatostatin receptor-interacting protein; SPANK 1; SPANK-1; SSTR-interacting protein; Synamon
基因别名: SHANK1; Shank1a; SPANK-1; Spank1; SSTRIP; synamon
UniProt ID: (Human) Q9Y566, (Rat) Q9WV48, (Mouse) D3YZU1
Entrez Gene ID: (Human) 50944, (Rat) 78957, (Mouse) 243961
protein binding
protein C-terminus binding
SH3 domain binding
GKAP/Homer scaffold activity
somatostatin receptor binding
protein complex binding
ionotropic glutamate receptor binding
identical protein binding
ankyrin repeat binding
scaffold protein binding
receptor signaling complex scaffold activity
protein complex assembly
cytoskeletal anchoring at plasma membrane
long-term memory
associative learning
adult behavior
negative regulation of actin filament bundle assembly
social behavior
protein localization to synapse
olfactory behavior
habituation
neuromuscular process controlling balance
determination of affect
righting reflex
synapse maturation
dendritic spine morphogenesis
positive regulation of dendritic spine development
vocalization behavior
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
positive regulation of excitatory postsynaptic potential
nervous system development
cell differentiation
