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Invitrogen
Shiga toxin 1 (Pritoxaximab Biosimilar) Recombinant Human Monoclonal Antibody
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产品信息
MA5-60165
应用
建议稀释比
已发表文章
产品规格
种属反应
Bacteria
宿主/亚型
Human
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
靶标信息
Shiga toxin 1 (Stx1) is produced by certain strains of Shigella dysenteriae and Escherichia coli, including strains that cause severe gastrointestinal diseases such as dysentery and hemorrhagic colitis. Structurally, Stx1 is an AB5 toxin, composed of one enzymatically active A subunit and five identical B subunits. The A subunit contains the N-glycosidase enzyme that inactivates the 28S ribosomal RNA, thereby halting protein synthesis and leading to cell death. The B subunits form a pentameric ring that binds to the glycolipid receptor Gb3 (globotriaosylceramide) on the surface of host cells, facilitating the entry of the A subunit into the cell. Functionally, Stx1 is highly cytotoxic and contributes to the pathogenicity of bacterial strains that produce it, leading to serious conditions such as hemolytic uremic syndrome (HUS) characterized by kidney failure, hemolytic anemia, and thrombocytopenia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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