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Invitrogen
Shiga toxin 2 (Setoxaximab Biosimilar) Recombinant Human Monoclonal Antibody
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Shiga toxin 2 (Setoxaximab Biosimilar) Antibody (MA5-41996) in SDS-PAGE
SDS-PAGE analysis of the recombinant Escherichia coli Stx2/SLT-II protein expressed in CHO cells using a Shiga toxin 2 (Setoxaximab Biosimilar) monoclonal antibody (Product # MA5-41996). R denotes the lane was run under reducing conditions. NR denotes the lane was run under non-reducing conditions.
产品信息
MA5-41996
产品规格
种属反应
Bacteria
宿主/亚型
Human
/ IgG1, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
抗原
Escherichia coli Stx2/SLT-II
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Endotoxin level < 0.01EU/µg by LAL method
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
MA5-41996 is a chimeric antibody. The variable regions from one species have been grafted to the backbone of the other species.
靶标信息
Shiga toxin 2 (Stx2) is another variant of the Shiga toxins produced by certain strains of Shigella dysenteriae and Escherichia coli. Structurally, like Shiga toxin 1, Stx2 is an AB5 toxin composed of one A subunit and five B subunits. The A subunit has an N-glycosidase activity that disrupts protein synthesis by cleaving a specific adenine residue from the 28S rRNA of the 60S ribosomal subunit, leading to cell death. The B subunits form a pentamer that binds to the glycosphingolipid receptor Gb3 (globotriaosylceramide) on the surface of host cells, facilitating the entry of the A subunit into the cells. Functionally, Stx2 is highly cytotoxic and plays a crucial role in the pathogenicity of the bacterial strains that produce it, leading to severe diseases such as hemolytic uremic syndrome (HUS), which is characterized by acute kidney failure, hemolytic anemia, and thrombocytopenia. Stx2 is known to be more potent and associated with more severe disease outcomes compared to Stx1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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