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Invitrogen
Sildenafil Recombinant Mouse Monoclonal Antibody (3A9)
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Sildenafil Antibody (MA566321) in SDS-PAGE
SDS-PAGE characterization of Sildenafil under reducing conditions. Lane M: Protein marker (kDa); Lane SDN: Purified Sildenafil Recombinant Monoclonal (Product # MA566321). Sildenafil showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-630.
产品信息
MA566321
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
3A9
抗原
Conjugate of SDN hapten and KLH.
偶联物
形式
Liquid
浓度
18.6 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Sildenafil, commonly recognized by its brand names Viagra and Revatio, is a selective phosphodiesterase type 5 (PDE5) inhibitor widely used to treat erectile dysfunction and pulmonary arterial hypertension. Structurally, sildenafil includes a pyrazolo[4,3-d]pyrimidin-7-one framework, which allows it to increase cyclic guanosine monophosphate (cGMP) levels by preventing PDE5 from breaking it down, thus facilitating smooth muscle relaxation and vasodilation in the corpus cavernosum. Administered orally, sildenafil undergoes hepatic metabolism predominantly by the CYP3A4 enzyme, with a half-life that supports effective therapeutic action for several hours. While generally well-tolerated, sildenafil can interact with nitrates and certain antihypertensive medications, leading to potentially serious cardiovascular effects, and may cause side effects ranging from headaches to visual disturbances. Ongoing research aims to explore its broader applications in treating conditions like Raynaud's phenomenon and enhancing athletic performance, constantly evaluating its safety and efficacy in various contexts.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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