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Invitrogen
Slc30A8 Polyclonal Antibody
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Slc30A8 Antibody (PA5-119426) in IHC (P)
Immunohistochemistry (Paraffin) analysis of SLC30A8 in mouse pancreas tissue using Slc30A8 Polyclonal Antibody (Product # PA5-119426) (10 µg/mL) and using PBS intead of the primary antibody as a control. The sample was then stained with HRP-Goat anti-Rabbit IgG polyclonal secondary antibody (2 µg/mL). DAB staining.
产品信息
PA5-119426
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein Solute Carrier Family 30 Member 8. The antigen corresponds to amino acid range 263-369 of the target protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography, Protein A
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Slc30A8 is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles and is expressed at a high level in the pancreas, particularly in islets of Langerhans, and co-localizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of Slc30A8 have been identified as major genetic risk factors for the development of Type 2 diabetes, but no genetic association has been found with Type 1 diabetes. Slc30A8 expression in b-cells was found to be influenced by cytokine expression, particularly IFN-gamma and IL-1 beta.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Proton-coupled zinc antiporter SLC30A8; solute carrier family 30 (zinc transporter), member 8; Solute carrier family 30 member 8; Zinc transporter 8; zinc transporter ZnT-8; ZnT-8
基因别名: C820002P14Rik; SLC30A8; ZnT-8; ZNT8
UniProt ID: (Human) Q8IWU4, (Mouse) Q8BGG0
Entrez Gene ID: (Human) 169026, (Mouse) 239436
zinc II ion transport
cellular zinc ion homeostasis
response to glucose
response to zinc ion
insulin secretion
positive regulation of insulin secretion
sequestering of zinc ion
response to interferon-gamma
glucose homeostasis
regulation of vesicle-mediated transport
regulation of sequestering of zinc ion
response to interleukin-1
zinc II ion transmembrane transport
transport
ion transport
cation transport
transmembrane transport
