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Alomone Labs, LTD
Slitrk1 (extracellular) Polyclonal Antibody
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Slitrk1 (extracellular) Antibody (ASR-081-200UL) in IHC (F)
Multiplex staining of Slitrk1 and KV2.1 in rat parietal cortex - Immunohistochemical staining of immersion-fixed, free floating rat brain frozen sections using rabbit Anti-Slitrk1 (extracellular) Antibody (#ASR-081), (1:200) andGuinea pig Anti-KV2.1 Antibody (#APC-012-GP), (1:200). A. Slitrk1 staining (red) appears in profiles of pyramidal neurons. B. KV2.1 staining (green) is detected in profiles of pyrami... View More
产品信息
ASR-081-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)RDNKIHSIRKSHFVD, corresponding to amino acid residues 383-397 of mouse Slitrk1, Extracellular, N-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
SLIT and NTRK-like family 1 (Slitrk1) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk1 is expressed primarily in mature neurons. Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites, while expression of the other Slitrk proteins inhibited neurite outgrowth, suggesting that these proteins are involved in the control of neurite outgrowth. While Slitrk1 variants have been suggested associated with Tourette's Syndrome, it is thought to play only a minor role if at all.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Leucine-rich repeat-containing protein 12; RP11-395N17.1; SLIT and NTRK-like family, member 1; SLIT and NTRK-like protein 1; slit and trk like gene 1
基因别名: 3200001I04Rik; KIAA1910; LRRC12; SLITRK1; Sltk1; TTM; UNQ233/PRO266
UniProt ID: (Human) Q96PX8, (Mouse) Q810C1
Entrez Gene ID: (Human) 114798, (Rat) 306147, (Mouse) 76965
