Invitrogen

Sodium Channel Pan Polyclonal Antibody

查看其他17个Sodium Channel Pan抗体

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
Sodium Channel Pan Polyclonal Antibody

产品信息

PA5-36543

应用
建议稀释比
已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:200
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to amino acids 1442-1496 of human Na+ CP type alpha-pan
查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 50% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2553578

产品详细信息

This antibody detects endogenous protein at a molecular weight of 226 kDa.

Purity is >95% by SDS-PAGE.

靶标信息

Voltage-gated sodium channels (NaV) are essential for the generation of action potentials and for cell excitability. NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine NaV alpha subunits have been cloned and named NaV1.1-NaV1.9. The NaV channels are classified into two groups according to their sensitivity to tetrodotoxin (TTX): TTX-sensitive (NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7) and TTX-resistant (NaV1.5, NaV1.8 and NaV1.9). Mammalian sodium channels are heterotrimers, composed of a central, pore-forming alpha subunit and two auxiliary beta subunits. The expression of the alpha subunit isoform is developmentally regulated and tissue specific. Sodium channels in the adult central nervous system and heart contain beta 1 through beta 4 subunits, whereas sodium channels in adult skeletal muscle have only the beta 1 subunit.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
引用该产品

生物信息学

蛋白别名: 3-Feb; alternative product; ataxia 3; brain III voltage-gated sodium channel; cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit; CTC-264K15.6; HBSC II; hH1; hNa6/Scn8a voltage-gated sodium channel; hNaN; hNE-Na; mH1; Mu-1; Na+ channel; NaCh6; NaN; Neuroendocrine sodium channel; Peripheral nerve protein type 4; Peripheral nerve sodium channel 3; Peripheral nerve sodium channel 5; Peripheral sodium channel 1; PN1; PN3; PN4; PN5; RIIA sodium channel protein; Sensory neuron sodium channel; Sensory neuron sodium channel 2; skeletal muscle sodium channel alpha subunit; skeletal muscle voltage-dependent sodium channel type IV alpha subunit; SkM1; sodium channel 25; Sodium channel 6; sodium channel alpha-subunit; Sodium channel protein brain I subunit alpha; Sodium channel protein brain II subunit alpha; Sodium channel protein brain III subunit alpha; Sodium channel protein cardiac muscle subunit alpha; Sodium channel protein skeletal muscle subunit alpha; Sodium channel protein type 1 subunit alpha; Sodium channel protein type 10 subunit alpha; Sodium channel protein type 11 subunit alpha; Sodium channel protein type 2 subunit alpha; Sodium channel protein type 3 subunit alpha; Sodium channel protein type 4 subunit alpha; Sodium channel protein type 5 subunit alpha; Sodium channel protein type 8 subunit alpha; Sodium channel protein type 9 subunit alpha; Sodium channel protein type I subunit alpha; Sodium channel protein type II subunit alpha; Sodium channel protein type III subunit alpha; Sodium channel protein type IV subunit alpha; Sodium channel protein type IX subunit alpha; Sodium channel protein type V subunit alpha; Sodium channel protein type VIII subunit alpha; Sodium channel protein type X subunit alpha; Sodium channel protein type XI subunit alpha; sodium channel protein, brain I alpha subunit; sodium channel protein, brain I subunit alpha; sodium channel protein, brain II subunit alpha; sodium channel protein, brain III subunit alpha; sodium channel protein, brain type 2 alpha subunit; sodium channel type X alpha polypeptide; sodium channel voltage gated type 1 alpha subunit; sodium channel voltage-gated type 11 alpha polypeptide; sodium channel voltage-gated type 4 alpha polypeptide; sodium channel voltage-gated type I alpha polypeptide; sodium channel voltage-gated type II alpha polypeptide; Sodium channel voltage-gated type IV alpha polypeptide; sodium channel voltage-gated type V alpha polypeptide; sodium channel voltage-gated type VIII alpha polypeptide; sodium channel voltage-gated type X alpha polypeptide; sodium channel voltage-gated type XI alpha polypeptide; sodium channel, voltage gated, type I alpha subunit; sodium channel, voltage gated, type II alpha subunit; sodium channel, voltage gated, type III alpha subunit; sodium channel, voltage gated, type IV alpha subunit; sodium channel, voltage gated, type IX alpha subunit; sodium channel, voltage gated, type V alpha subunit; sodium channel, voltage gated, type VIII alpha subunit; sodium channel, voltage gated, type VIII, alpha subunit; sodium channel, voltage gated, type X alpha subunit; sodium channel, voltage gated, type XI alpha subunit; sodium channel, voltage-gated, type 1, alpha polypeptide; sodium channel, voltage-gated, type 10, alpha polypeptide; sodium channel, voltage-gated, type 11, alpha polypeptide; sodium channel, voltage-gated, type 2, alpha 1 polypeptide; sodium channel, voltage-gated, type 2, alpha 1 subunit; sodium channel, voltage-gated, type 3, alpha subunit; sodium channel, voltage-gated, type 4, alpha polypeptide; sodium channel, voltage-gated, type 4, alpha subunit; sodium channel, voltage-gated, type 5, alpha subunit; sodium channel, voltage-gated, type 8, alpha polypeptide; sodium channel, voltage-gated, type 8, alpha subunit; sodium channel, voltage-gated, type 9, alpha polypeptide; sodium channel, voltage-gated, type I, alpha polypeptide; sodium channel, voltage-gated, type I, alpha subunit; sodium channel, voltage-gated, type II, alpha 1; sodium channel, voltage-gated, type II, alpha 1 polypeptide; sodium channel, voltage-gated, type II, alpha 2 polypeptide; sodium channel, voltage-gated, type II, alpha polypeptide 1; sodium channel, voltage-gated, type II, alpha subunit; sodium channel, voltage-gated, type III, alpha polypeptide; sodium channel, voltage-gated, type IV, alpha polypeptide; sodium channel, voltage-gated, type IV, alpha subunit; sodium channel, voltage-gated, type IX, alpha polypeptide; sodium channel, voltage-gated, type IX, alpha subunit; sodium channel, voltage-gated, type V, alpha polypeptide; sodium channel, voltage-gated, type V, alpha subunit; sodium channel, voltage-gated, type VIII, alpha polypeptide; sodium channel, voltage-gated, type X, alpha polypeptide; sodium channel, voltage-gated, type X, alpha subunit; sodium channel, voltage-gated, type XI, alpha polypeptide; sodium channel, voltage-gated, type XI, alpha subunit; sodium channel, voltage-gated, type XII, alpha polypeptide; sodium channel, voltage-gated, type11, alpha polypeptide; SP-19; voltage gated sodium channel; voltage-gated sodium channel alpha subunit Nav1.7; voltage-gated sodium channel Nav1.5c; voltage-gated sodium channel NAV1.9b; voltage-gated sodium channel subtype II; Voltage-gated sodium channel subtype III; Voltage-gated sodium channel subunit alpha Nav1.1; Voltage-gated sodium channel subunit alpha Nav1.2; Voltage-gated sodium channel subunit alpha Nav1.3; Voltage-gated sodium channel subunit alpha Nav1.4; Voltage-gated sodium channel subunit alpha Nav1.5; Voltage-gated sodium channel subunit alpha Nav1.6; Voltage-gated sodium channel subunit alpha Nav1.7; Voltage-gated sodium channel subunit alpha Nav1.8; Voltage-gated sodium channel subunit alpha Nav1.9; voltage-gated sodium channel type II alpha subunit; voltage-gated sodium channel type VIII alpha protein

查看更多 收起

基因别名: 6430408L10; A230052E19Rik; AI853486; B230332M13; BFIC3; BFIS3; BFNIS; C630029C19Rik; CDCD2; CERIII; CIAT; CMD1E; CMPD2; CMS16; dmu; EIEE11; EIEE13; EIEE6; ETHA; FEB3; FEB3A; FEB3B; FEPS2; FEPS3; FHM3; GEFSP2; GEFSP7; Gm1000; HB1; HB2; HBA; HBBD; HBSCI; HBSCII; HH1; HOKPP2; hPN3; HSAN2D; HSAN7; HYKPP; HYPP; ICCD; IVF; KIAA1356; Kiaa4197; LQT3; MED; mH1; mH2; microI; mKIAA4197; mnd-2; mnd2; Na(v)1.2; Na(V)1.4; Na(V)1.8; NAC1; NAC1A; NAC2; NAC3; NaCh6; NachII; NaN; NaT; Nav1.1; Nav1.2; Nav1.3; Nav1.4; Nav1.5; Nav1.5c; Nav1.6; Nav1.7; Nav1.8; NAV1.9; Nbna1; NCHVS; NE-NA; NENA; nmf2; nmf335; nmf58; NSS2; nur14; PFHB1; PN1; PN3; PN4; PN5; RII/RIIA; RNSCPIIR; SCAL; SCIII; SCN; SCN1; SCN10A; SCN11A; SCN12A; SCN1A; SCN2A; SCN2A1; SCN2A2; SCN3A; SCN4A; SCN5A; SCN8A; SCN9A; ScpII; seal; SFNP; SkM1; SkM2; SMEI; SNS; SNS-2; SNS2; SSS1; VF1

查看更多 收起

UniProt ID: (Human) Q9Y5Y9, (Human) Q9UI33, (Human) P35498, (Human) Q99250, (Human) Q9NY46, (Human) P35499, (Human) E9PEK2, (Human) Q9UQD0, (Human) Q15858, (Rat) Q62968, (Mouse) Q6QIY3, (Rat) O88457, (Mouse) Q9R053, (Rat) P04774, (Mouse) A2APX8, (Rat) P04775, (Mouse) B1AWN6, (Mouse) A2ASI5, (Rat) P08104, (Mouse) Q9ER60, (Rat) P15390, (Rat) P15389, (Mouse) Q9JJV9, (Mouse) Q9WTU3, (Rat) O88420, (Mouse) Q62205, (Rat) O08562

查看更多 收起

Entrez Gene ID: (Human) 6336, (Human) 11280, (Human) 6323, (Human) 6326, (Human) 6328, (Human) 6329, (Human) 6331, (Human) 6334, (Human) 6335, (Rat) 29571, (Mouse) 20264, (Rat) 29701, (Mouse) 24046, (Rat) 81574, (Mouse) 20265, (Rat) 24766, (Mouse) 110876, (Mouse) 20269, (Rat) 497770, (Mouse) 110880, (Rat) 25722, (Rat) 25665, (Mouse) 20271, (Mouse) 20273, (Rat) 29710, (Mouse) 20274, (Rat) 78956

查看更多 收起

功能
voltage-gated sodium channel activity ion channel binding sodium ion binding calmodulin binding protein binding fibroblast growth factor binding enzyme binding protein kinase binding protein domain specific binding ankyrin binding ubiquitin protein ligase binding nitric-oxide synthase binding voltage-gated sodium channel activity involved in cardiac muscle cell action potential voltage-gated sodium channel activity involved in AV node cell action potential voltage-gated sodium channel activity involved in bundle of His cell action potential voltage-gated sodium channel activity involved in Purkinje myocyte action potential voltage-gated sodium channel activity involved in SA node cell action potential scaffold protein binding ATP binding ion channel activity voltage-gated ion channel activity sodium channel activity leucine zipper domain binding nucleotide binding voltage-gated ion channel
参与通路
regulation of heart rate sensory perception neuronal action potential sensory perception of pain regulation of ion transmembrane transport sodium ion transmembrane transport odontogenesis of dentin-containing tooth regulation of cardiac muscle contraction regulation of postsynaptic membrane potential regulation of atrial cardiac muscle cell membrane depolarization membrane depolarization during action potential AV node cell action potential bundle of His cell action potential sodium ion transport response to drug regulation of sensory perception of pain positive regulation of defense response to virus by host adult walking behavior neuronal action potential propagation neuromuscular process controlling posture xenophagy intrinsic apoptotic signaling pathway in response to osmotic stress myelination neuron apoptotic process nervous system development response to wounding response to pyrethroid cellular response to antibiotic potassium ion transport muscle contraction choline transport cardiac ventricle development brainstem development positive regulation of sodium ion transport response to denervation involved in regulation of muscle adaptation telencephalon development cerebellum development positive regulation of action potential positive regulation of epithelial cell proliferation membrane depolarization cardiac muscle contraction regulation of ventricular cardiac muscle cell membrane repolarization regulation of atrial cardiac muscle cell membrane repolarization regulation of ventricular cardiac muscle cell membrane depolarization cardiac conduction cellular response to calcium ion cardiac muscle cell action potential involved in contraction regulation of cardiac muscle cell contraction ventricular cardiac muscle cell action potential membrane depolarization during cardiac muscle cell action potential SA node cell action potential membrane depolarization during AV node cell action potential membrane depolarization during SA node cell action potential membrane depolarization during Purkinje myocyte cell action potential membrane depolarization during bundle of His cell action potential AV node cell to bundle of His cell communication regulation of heart rate by cardiac conduction regulation of sodium ion transmembrane transport peripheral nervous system development inflammatory response response to toxic substance post-embryonic development behavioral response to pain bundle of His cell to Purkinje myocyte communication transport ion transport transmembrane transport action potential regulation of membrane potential cation transport positive regulation of heart rate response to organic cyclic compound SA node cell to atrial cardiac muscle cell communication muscle organ development sensory perception of sound locomotory behavior adult locomotory behavior neuromuscular process rhythmic excitation
guarantee_icon

性能保障

只要您发现Invitrogen抗体在实验中的表现与网站或说明书的所述内容不符，您即可享受免费退换货服务。*

了解更多
help_icon

随时为您服务

获取常见问题的专家解答，或者直接联系我们的技术专家，咨询应用、设备、常规产品使用问题。

联系技术支持