Product References
A point mutation in the Pdia6 gene results in loss of pancreatic β-cell identity causing overt diabetes.
Molecular metabolism
Chhabra NF,Amend AL,Bastidas-Ponce A,Sabrautzki S,Tarquis-Medina M,Sachs S,Rubey M,Lorenz-Depiereux B,Feuchtinger A,Bakhti M,Lickert H,Przemeck GKH,Hrabě de Angelis M
MA5-16987 was used in Immunohistochemistry (PFA fixed) to demonstrate that a global Pdia6 mutation renders mice hypoinsulinemic and hyperglycemic due to loss of pancreatic β-cell function and identity.
Wed Dec 01 00:00:00 EST 2021
A point mutation in the Pdia6 gene results in loss of pancreatic β-cell identity causing overt diabetes.
Molecular metabolism
Chhabra NF,Amend AL,Bastidas-Ponce A,Sabrautzki S,Tarquis-Medina M,Sachs S,Rubey M,Lorenz-Depiereux B,Feuchtinger A,Bakhti M,Lickert H,Przemeck GKH,Hrabě de Angelis M
MA5-16987 was used in Immunohistochemistry (PFA fixed) to demonstrate that a global Pdia6 mutation renders mice hypoinsulinemic and hyperglycemic due to loss of pancreatic β-cell function and identity.
Wed Dec 01 00:00:00 EST 2021
Pancreatic cancer triggers diabetes through TGF-β-mediated selective depletion of islet β-cells.
Life science alliance
Parajuli P,Nguyen TL,Prunier C,Razzaque MS,Xu K,Atfi A
Published figure using Somatostatin monoclonal antibody (Product # MA5-16987) in Immunohistochemistry
Mon Jun 01 00:00:00 EDT 2020
Pancreatic cancer triggers diabetes through TGF-β-mediated selective depletion of islet β-cells.
Life science alliance
Parajuli P,Nguyen TL,Prunier C,Razzaque MS,Xu K,Atfi A
Published figure using Somatostatin monoclonal antibody (Product # MA5-16987) in Immunohistochemistry
Mon Jun 01 00:00:00 EDT 2020
Pancreatic cancer triggers diabetes through TGF-β-mediated selective depletion of islet β-cells.
Life science alliance
Parajuli P,Nguyen TL,Prunier C,Razzaque MS,Xu K,Atfi A
Published figure using Somatostatin monoclonal antibody (Product # MA5-16987) in Immunohistochemistry
Mon Jun 01 00:00:00 EDT 2020
Point mutations in the PDX1 transactivation domain impair human β-cell development and function.
Molecular metabolism
Wang X,Sterr M,Burtscher I,Böttcher A,Beckenbauer J,Siehler J,Meitinger T,Häring HU,Staiger H,Cernilogar FM,Schotta G,Irmler M,Beckers J,Wright CVE,Bakhti M,Lickert H
MA5-16987 was used in Immunocytochemistry-immunoflourescence to reveal mechanistic details of how common coding mutations in PDX1 impair human pancreatic endocrine lineage formation and Β-cell function and contribute to the predisposition for diabetes.
Sat Jun 01 00:00:00 EDT 2019
Point mutations in the PDX1 transactivation domain impair human β-cell development and function.
Molecular metabolism
Wang X,Sterr M,Burtscher I,Böttcher A,Beckenbauer J,Siehler J,Meitinger T,Häring HU,Staiger H,Cernilogar FM,Schotta G,Irmler M,Beckers J,Wright CVE,Bakhti M,Lickert H
MA5-16987 was used in Immunocytochemistry-immunoflourescence to reveal mechanistic details of how common coding mutations in PDX1 impair human pancreatic endocrine lineage formation and Β-cell function and contribute to the predisposition for diabetes.
Sat Jun 01 00:00:00 EDT 2019