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Invitrogen
Sonavibart Recombinant Human Monoclonal Antibody
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产品信息
MA562764
应用
建议稀释比
已发表文章
产品规格
种属反应
Virus
宿主/亚型
Human
/ IgG1, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Sonavibart is a biosimilar antibody designed to target and neutralize the influenza virus hemagglutinin (HA). The hemagglutinin (HA) gene of the influenza A virus encodes a surface glycoprotein essential for viral infectivity. Hemagglutinin is a trimeric protein that facilitates viral entry into host cells by binding to the sialic acid residues on the surface of the host epithelial cells. This binding event triggers endocytosis of the virus and subsequently mediates fusion between the viral envelope and the endosomal membrane, allowing the viral RNA to enter the host cell. Structurally, HA is a versatile molecule with a head and stem region, where the head contains the receptor-binding sites and the stem is involved in the membrane fusion process. The HA gene is highly prone to mutations, leading to antigenic drift and shift, contributing to the virus's rapid evolution and the need for continual vaccine updates. Recent studies have also revealed novel epitopes, particularly in the HA head domain, which are recognized by broad-spectrum human antibodies, offering insights into potential therapeutic targets.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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