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Invitrogen
Sonepcizumab Humanized Recombinant Human Monoclonal Antibody
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产品信息
MA5-59795
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
靶标信息
Sonepcizumab, also referred to as LT1009, is a humanized monoclonal antibody that targets sphingosine 1-phosphate (S1P), a signaling lipid active in promoting angiogenesis and tumor growth. Sphingosine-1-phosphate (S1P) is a critical lysolipid involved in multiple biological functions, including heart development, immune response, and hearing. It is a metabolite from cell membrane sphingolipids and is primarily regulated through its binding to specific G protein-coupled receptors named S1P receptors (S1PRs). These receptors are ubiquitously expressed in the human body, influencing various physiological and pathological processes. The signaling pathways initiated by S1P-S1PR interactions are crucial for immune cell trafficking, activation, and adaptive immune responses. Studies also highlight the role of S1P in regulating vascular stability, endothelial cell function, and as a mediator in inflammatory responses. The SPNS2 gene encodes a transporter protein essential for the active secretion of S1P, further emphasizing its relevance in maintaining physiological homeostasis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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