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Sortilin Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
OSS00041G-500UG
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide from rat Sortilin conjugated to blue carrier protein was used as the antigen
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
Conc. Not Determined
规格
500 µg
纯化类型
Ammonium sulfate precipitation
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: Sortilin.
靶标信息
Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Sortilin is required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). It is also required for protein transport from the Golgi apparatus to the endosomes. Sortilin promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also, Sortilin acts as a receptor for neurotensin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: glycoprotein 110; gp110; mNTR3; neurotensin receptor 3; novel candidate sorting receptor; NTR3; unnamed protein product
基因别名: 2900053A11Rik; Nt3; Ntr3; Nts3; Ntsr3
UniProt ID: (Mouse) Q6PHU5, (Rat) O54861
Entrez Gene ID: (Mouse) 20661, (Rat) 83576
protein targeting to lysosome
Golgi to plasma membrane transport
Golgi to endosome transport
endocytosis
G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
endosome to lysosome transport
extrinsic apoptotic signaling pathway via death domain receptors
regulation of gene expression
myotube differentiation
vesicle organization
endosome transport via multivesicular body sorting pathway
response to insulin
nerve growth factor signaling pathway
negative regulation of fat cell differentiation
neurotrophin TRK receptor signaling pathway
plasma membrane to endosome transport
Golgi to lysosome transport
glucose import across plasma membrane
maintenance of synapse structure
positive regulation of epithelial cell apoptotic process
intracellular protein transport
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